Uso do laser de baixa intensidade (GaAlAs) na prevenção de mucosite bucal em pacientes submetidos a transplante de medula óssea

• Ano de defesa: 2006
• Autor(a) principal: SILVA, Geisa Badauy Lauria
• Orientador(a): SILVA, Maria Alves Garcia Santos
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Goiás
• Programa de Pós-Graduação: Mestrado em Odontologia
• Departamento: Ciência da Saúde
• País: BR
• Palavras-chave em Português: Mucosa Bucal / Mucosite; Terapia a Laser de Baixa Intensidade; Transplante
• Palavras-chave em Inglês: Stomatitis [mucositis]; Laser Therapy, Low-Level; Bone Marrow Transplantation
• Área do conhecimento CNPq: CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA::CLINICA ODONTOLOGICA
• Link de acesso: http://repositorio.bc.ufg.br/tede/handle/tde/1385

Oral mucositis is one of the most debilitating complications in patients undergoing bone marrow transplants, occurring 50 to100% in these patients. The oral mucositis treatment and prevention is not completely defined, although the low intensity laser is widely used. The aim of the current study was to investigate the use of low intensity laser (GaAlAs) in the prevention of oral mucositis induced by conditioning regimen in patients undergoing bone marrow transplants. The study was a clinical trial and a total of 42 subjects undergoing allogenic and autologus bone marrow transplant at Araujo Jorge Cancer Hospital of the Combact Cancer Association of Goiás were enrolled. All patients received a high dose chemotherapy conditioning regimen associated or not with total body radiation. The Experimental Group received the hospital protocol of oral hygiene and preventive irradiation of low level laser (660nm) on day -4 (D-4) through post-transplant day 4 (D+4). The Control Group received just the hospital protocol of oral hygiene. Oral mucositis degree was evaluated daily according to the World Health Organization Scale (WHO) on day -2 until the wound healing. The Group which low level laser treatment was performed prophylactically, 57,1% of patients were free from mucositis and no one showed mucositis degree III and IV. The difference between both Groups related to the occurrence (p<0,001) and severity (p<0,008) of oral mucositis were statistically meanful. It was concluded that the low level laser treatment, prophylactically reduces the occurrence and severity of oral mucositis