Avaliação dos parâmetros físicos, hemagasométricos e metabolismo oxidativo em ovinos intoxicados com cobre, tratados ou não com tetratiomolibdato

Detalhes bibliográficos
Ano de defesa: 2008
Autor(a) principal: ALVES, Kilder Henrique Guimarães lattes
Orientador(a): SOARES, Pierre Castro
Banca de defesa: SUCUPIRA, Maria Claudia Araripe, SILVA, José Augusto Bastos Afonso da, COLE, Eduardo Ferreira
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal Rural de Pernambuco
Programa de Pós-Graduação: Programa de Pós-Graduação em Ciência Veterinária
Departamento: Departamento de Medicina Veterinária
País: Brasil
Palavras-chave em Português:
Palavras-chave em Inglês:
Área do conhecimento CNPq:
Link de acesso: http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/5725
Resumo: Ten Santa Inês lambs were used to study the effects of cumulative copper poisoning and the treatment with ammonium tetrathiomolybdate (TTM) on clinical profile, blood gas and oxidative metabolism. The lambs were drenched with increasing doses of copper sulfate until the onset of macroscopic hemoglobinuria. So the lambs were randomly distributed in two groups of five sheep each and treated (TTM) or not (C) with tetrathiomolybdate (3.4 mg/kg BW/ per day, for four days). All sheep C succumbed in four days of hemoglobinuria, while only one lamb died in the other group. The poisoning caused a typical clinical picture, creating major changes in various clinical parameters, together with determination of metabolic disorder, characterized by respiratory acidosis and metabolic alkalosis. With regard to the framework toxic oxidative metabolism caused intense formation of free radicals, showing a high serum malondialdehyde, reduction in the level of erythrocyte glutathione reduced, and increased the capacity anti-oxidant in plasma. High copper concentration in blood resulted in larger lipoperoxidation. The appropriate use of TTM in this status provided reduction in the formation of free radicals, increased the concentration of reduced erythrocyte glutathione, and also promoted gradual improvement of the clinical signs, clinical and gasometrical profile.