Comportamento do cálcio e fósforo plasmáticos, em pacientes com hipoparatireoidismo, após administração de carbonato de cálcio em diferentes formas de ingestão

• Ano de defesa: 2015
• Autor(a) principal: Gollino, Loraine [UNESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Estadual Paulista (Unesp)
• Palavras-chave em Português: Carbonato de calcio; Hipoparatireoidismo; Fosforo no organismo; Tireoidectomia; Homeostase; Thyroidectomy; Phosphorus in the body
• Link de acesso: http://hdl.handle.net/11449/131933; http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/02-10-2015/000850650.pdf

Introduction: In hypoparathyroidism, calcium supplementation is required (Ca) for controlling hypocalcemia, which is performed mostly calcium carbonate (CaCO3). There are doubts about the best way to intake of CaCO3 in fasting or after meals. Objective: The main objective of the study was to evaluate, in women with hypoparathyroidism after total thyroidectomy, serum concentrations of Ca, phosphorus (P) and Ca.P product evolution over 5 hours to peak, time to peak maximum and area under the curve (AUC) after supplementation with CaCO3 ingested in three different ways [fasting with water (W); fasting with orange juice (J); with breakfast (B), with water]. Casuistics and methods: The study design was a cross over type study, conducted with 12 adult women patients between 18 and 50 years of age with hypoparathyroidism after total thyroidectomy, evaluated in three different situations, with an interval of one week. In each situation, before and 30 each for 5 hours, after ingestion of CaCO3 (500 mg of elemental Ca). Were evaluated the evolution of Ca, P and serum Ca.P product beyond the maximum peak time for this peak and AUC for these parameters. Results: The mean values of Ca, P and Ca.P product remained, respectively, close to the lower limit, within the normal range and below the reference level, the period evaluated. However, some individual values of Ca and P were out of the normal range. The mean values of Ca, P and Ca.P product to the peak value (8.63 mg/dL for W, 8.77 mg/dL for J and 8.95 mg/dL for B; 4.04 mg/dL to W, 4.03 mg/dL for J and 4.12 mg/dL for B; 34.3 mg2/dL2 for W, 35.8 mg2/dL2 for J and 34.5 mg2/dL2 for B, respectively), time to peak (202.5 min for W, 182.5 min for J and 152.5 min for B; 142 min for W, 135 min for J and 167 min for B; 180 min for W, 187 min for J and 192 min for B, respectively) and AUC (2433 mg/dL.min for W, 2506 mg/dL.min J and 2577 mg/dL.min for B; 105 mg/dL.min for W, 105 mg/dL.min. for J and ...