Efeitos determinados pela administração subaracnoidea de dexmedetomidina, em dose única, sobre a medula espinal e as meninges de coelhos

Detalhes bibliográficos
Ano de defesa: 2015
Autor(a) principal: Cardoso, Hugo Eckener Dantas de Pereira [UNESP]
Orientador(a): Não Informado pela instituição
Banca de defesa: Não Informado pela instituição
Tipo de documento: Tese
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Estadual Paulista (Unesp)
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Link de acesso: http://hdl.handle.net/11449/142981
http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/05-07-2016/000865035.pdf
Resumo: Background: dexmedetomidine is a dextrorotatory enantiomer of medetomidine, has important sedative and analgesic actions. This drug is used as premedication or associated with anesthesia by intravenous, muscular, epidural or subarachnoid. Clinical studies show that when used in the epidural space of human's dexmedetomidine did not cause neurological damage. By subarachnoid way the association of small drug doses (3-10 μg) with the anesthetic resulted in an increase in the time of sensory and motor block, maintaining hemodynamic stability and some degree of sedation. Studies on the effects of dexmedetomidine introduced into the subarachnoid space, besides scarce do not ensure that the agent does not cause neurological damage. Objective: to evaluate the effects of dexmedetomidine, administered by the intrathecal route in single dose, determines on the spinal cord and meninges of rabbits. Method: twenty young adult female rabbits, weighing 3200-4900 g with 36 spine length and 40 cm were divided by lot into two groups (G ): 0.9% saline G1, G2 dexmedetomidine (10 μg). After intravenous anesthesia with ketamine and xylazine spinal puncture was performed in S1 - S2 ultrasound guided and injected a random solution. The animals remained in captivity for 21 days under medical observation and were sacrificed by decapitation and removal of the lumbosacral portion of the spinal cord for histologic examination [hematoxylin and eosin (HE)] and immunohistochemistry for glial fibrillary acidic protein (GFAP). Results: no animal showed histological lesions of nerve tissue; however 9 animals showed changes in meninges. Conclusions: in this experimental model in rabbits dexmedetomidine triggered no histological lesions of nerve tissue, but showed changes in meninges