Efeito de suplementação de complexo B na concentração de homocisteína e perfil lipídico na pós-menopausa

• Ano de defesa: 2018
• Autor(a) principal: Banzoli, Carolina Vicente [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Homocysteine; Postmenopause; Lipid profile; Homocisteína; Menopausa; Dislipidemia; Multivitamínico; Risco cardiovascular
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=6394997; https://repositorio.unifesp.br/handle/11600/52898

Introduction: Cardiovascular diseases (CVD) are the main cause of death in Western countries. A homocysteine (Hcy) is an important risk factor for coronary artery disease. With population growth, life expectancy for women in Brazil rose from 79.1 years, according to the 2015 census (IBGE, 2010). Given this scenario women will spend 1/3 of their lives in the postmenopausal and consequently without estrogen protection, which is already a risk factor for hyperhomocysteinemia. It is known that the vitamins pyridoxine, cyanocobalamin and folic acid are important co-factors in the metabolism of Hcy, and their deficiency may lead to an increase in Hcy plasma levels. Objective: To evaluate the effects of to assess the effects of multivitamin (pyridoxine hydrochloride 4.00 mg + folic acid 0.80 mg + cyanocobalamin 0.40 mg) on plasma Hcy plasma concentrations and lipid profile of postmenopausal women. Methods: A double-blind randomized clinical trial with an unqualified mask of convenience selected 60 postmenopausal women from the Climateric outpatient clinic at Casa de Saúde Santa Marcelina, who routinely consulted and met the inclusion criteria. Women were randomly assigned to the control or intervention group (30 in each group). The group will be delivered daily and the control group will be compressed with the organoleptic characteristics of the compound for a period of 4 months. The women were evaluated before and after 4 months of the beginning of the intervention. The following variables were analyzed in health worksheets: anthropometric measures, total cholesterol and fractions, triglycerides, fasting glycemia, Hcy, and analyzed by SPPS version 21, using the GEE test, with a significance level of 5%. Results: There was a significant decrease in Hcy in the intervention group compared to the control group when patients with HDL <50 μg / dL (p=0,01 IC= [0,133 – 0,518]). were analyzed. Conclusions: Multivitamin supplementation consisting of pyridoxine, cyanocobalamin, and folic acid was effective in decreasing plasma Hcy levels in women with decreased HDL. We conclude that B complex supplementation may be beneficial in postmenopausal patients in order to decrease the plasma Hcy level.