Correção de ruptura de ligamento cruzado em cães com implante de polipropileno associado a fração total de células mononucleares

• Ano de defesa: 2010
• Autor(a) principal: Müller, Daniel Curvello de Mendonça
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Santa Maria; BR; Medicina Veterinária; UFSM; Programa de Pós-Graduação em Medicina Veterinária
• Palavras-chave em Português: Desmotomia do ligamento cruzado; Implante sintético; Células-tronco; Desmotomia cruciate ligament; Synthetic implants; Stem cells; CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA
• Link de acesso: http://repositorio.ufsm.br/handle/1/4071

The ligament rupture (LC) is lesion diagnosed in most dogs with joint problems, and the most common cause is degenerative joint disease of the knee joint. This study aimed to evaluate the action of the total fraction of mononuclear cells from autologous bone marrow (FCMO) applied intra-articular by after surgical repair of ruptured cruciate ligament. It is proposed a new technique for surgical correction of this disease, evaluating clinically the action of a polypropylene mesh as the only substitute for cranial cruciate ligament and flow of dogs. Twenty dogs underwent unilateral desmotomy cranial and caudal LC. Twenty-one days after the break, all were treated surgically by the technique of open reduction, with implantation of polypropylene replacing only the cranial cruciate ligament (CCL). Ten animals received FCMO at the time of correction. The assessments were by X-ray study, clinical examinations and biopsies at 50 and 90 days postoperatively. The surgical technique has shown rapid implementation and low soft tissue dissection, early return to ambulation and adequate strength of the implant. The group that received FCMO grew intra-articular bone at the X-ray study, however, the twenty animals showed CD34 positive in their biopsy samples, indicating a presence of stem cells in both groups. It was concluded that there was no clinical difference between the two groups until 90 days of evaluation.