Associação entre atividade física, aptidão cardiorrespiratória e biomarcadores inflamatórios em adultos jovens saudáveis

• Ano de defesa: 2013
• Autor(a) principal: Moreno, Carlos Marcelo Cuello
• Orientador(a): Hallal, Pedro Rodrigues Curi
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Pelotas
• Programa de Pós-Graduação: Programa de Pós-Graduação em Educação Física
• Departamento: Escola Superior de Educação Física
• País: BR
• Palavras-chave em Português: Biomarcadores inflamatórios; Proteína C-reativa; Atividade física
• Palavras-chave em Inglês: Inflammatory biomarkers; C-reactive protein; Physical activity; Cardiorespiratory fitness
• Área do conhecimento CNPq: CNPQ::CIENCIAS DA SAUDE::EDUCACAO FISICA
• Link de acesso: https://guaiaca.ufpel.edu.br/handle/123456789/1792

Low-intensity chronic systemic inflammation is related to an increased risk of cardiovascular disease. Studies suggest that C-reactive protein, one of the main inflammatory biomarkers, may be inversely related to physical activity levels and physical fitness. The aim of this cross-sectional study was to evaluate the associations between physical activity, fitness and inflammatory biomarkers in apparently healthy men (N=85) aged 18 to 30 years. C-reactive protein was measured using the ELISA method. Physical activity practice was assessed by questionnaire and accelerometry. Maximum oxygen uptake (VO2max) was estimated based on a cycle ergometer incremental test. In the unadjusted analysis, the mean concentrations of C-reactive protein in the sample was 1.59±1.16 mg/L, and was inversely correlated with VO2max (r=-0.32, p=0.03). The body mass index (BMI) and waist circumference also significantly correlated with C-reactive protein (r=0.37, p<0.001 and r=0.41, p<0.001, respectively). After adjustment for anthropometric characteristics (BMI and waist circumference), the association with fitness was no longer significant. No association was observed between physical activity levels (questionnaire and accelerometry) and C-reactive protein. We conclude the in this group of young adults there was an inverse association between fitness and C-reactive protein, and this association is explained by the influence of fitness on anthropometry.