Sono e memória em pacientes com esquizofrenia e parentes não acometidos

• Ano de defesa: 2016
• Autor(a) principal: Ventura, Jayana Ramalho
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal da Paraíba; Brasil; Psicologia; Programa de Pós-Graduação em Neurociência Cognitiva e Comportamento; UFPB
• Palavras-chave em Português: Esquizofrenia; Parentes; Memória; Sono; Schizophrenia; Relatives; Memory; Sleep; CNPQ::CIENCIAS HUMANAS::PSICOLOGIA
• Link de acesso: https://repositorio.ufpb.br/jspui/handle/123456789/14866

Schizophrenia is a neuropsychiatric disorder that predisposes genetic, behavioral and cognitive factors. The symptomatology of schizophrenia causes damage to behavioral sleep factors, which in turn are associated with plasticity and consolidation of neurocognitive processes. This study aimed to evaluate the effect of sleep quality of schizophrenic patients and their non - affected relatives on working memory and executive functions. It was divided into two articles: (I) Cognitive Functions of Schizophrenia and Unrelated Relatives: A Systematic Review, conducted a review in the literature on the cognitive and sleep quality aspects of schizophrenic patients and their non-psychotic relatives. The Pubmed and Medline databases were used as a tool during the period from 2000 to 2015. Schizophrenia associated with the following keywords: “memory”, “attention” and “executive function” was evaluated in combination with the words “siblings AND sleep”: Of the 421 articles found, four met the inclusion criteria. The results showed that there is cognitive deficit of memory, attention and executive functions in schizophrenic patients and their non-affected relatives associated with delays in the delta waves of the sleep spindles; (II) Sleep and Memory in Patients with Schizophrenia and Unrelated Relatives, assessed aspects of sleep quality and associated measures of memory and executive functions of schizophrenic patients and their non-affected relatives. A total of 85 subjects of both sexes, aged between 24 and 58 years old, were divided into three groups: schizophrenic (GEez: n = 25; M = 44.52; SD = 7.4); relatives not affected (GEp: n = 30; M = 41.93; SD = 10.5); healthy controls (GC: n = 30; M = 38.17; SD = 8.6). The Pittsburgh Sleep Quality Questionnaire and the Hörne and Ostberg Chronotype Identification Questionnaire, and ReyOsterriech's Complex Neuropsychological Tests and Sequence of numbers and letters. The results showed a significant difference in sleep quality in GC when compared to GEez (U = 26.5; z = -5.96; p < 0.001) and GEp (U = 238.5; z = -3.21; p < 0.01), and in the tests of Rey Complex Figure copy memory and in the Sequence of Numbers and Letters the GC presented better gross score when compared to GEez (U = 26.5; z = -5.96; p < 0.001 ) and GEp (U = 238.5; z = -3.21; p < 0.01). We conclude that subjects with Schizophrenia and their non-affected relatives have alterations in behavioral aspects of sleep as well as in the neurocognitive processes of working memory and executive functions.