Avaliação dos níveis de melatonina e mediadores inflamatórios na infecção por Leishmania em pacientes hiperglicêmicos

Detalhes bibliográficos
Ano de defesa: 2021
Autor(a) principal: Martins, Thalissa Mariana de Moraes
Orientador(a): Não Informado pela instituição
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal de Mato Grosso
Brasil
Instituto de Ciências Biológicas e da Saúde (ICBS) – Araguaia
UFMT CUA - Araguaia
Programa de Pós-Graduação em Imunologia e Parasitologia Básicas e Aplicadas
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Link de acesso: http://ri.ufmt.br/handle/1/5661
Resumo: American Cutaneous Leishmaniasis (ACL) is a neglected zoonotic disease that affects the skin and mucous membranes, resulting in single or multiple ulcerative lesions. Type 2 Diabetes Mellitus (T2DM) is a metabolic disorder, consisting of chronic hyperglycemia, resulting from failure in insulin secretion and/or action, representing a serious and growing health problem and one of the main causes of mortality in the world. Commonly, infectious diseases are more recurrent in diabetic patients, due to immune dysfunction. Marked and chronic inflammation is a common feature in these two comorbidities. The hormone melatonin is an endogenously synthesized indolamine, exerting important immunomodulatory and neuroprotective actions, in addition to the temporal maintenance of the biological rhythm. Knowledge about the effect of Leishmania infection on the biological clock of the host is still scarce, therefore, the objective of this work was to evaluate the relationship of melatonin with inflammatory mediators in Leishmania infection in hyperglycemic patients. Serum levels of the hormone melatonin, glucose and inflammatory mediators (CRP, IL-4, TNF-α) were evaluated in healthy individuals, with leishmaniasis, with diabetes and with an association of both diseases. An increase in TNF-α was observed in the test groups in relation to the control. In addition, reduced levels of melatonin in the ACL group (43.12±4.44 pg.mL-1 ), with a significant difference in relation to the control group (60.79±12.09 pg.mL-1 ), were observed higher melatonin concentrations of the ACL +DMT2 group (69.65±7.03 pg.mL-1 ) in relation to the isolated groups. Our study provides evidence to consider that TNF-α may affect melatonin production in patients with cutaneous leishmaniasis. On the other hand, diabetic patients affected by ACL had melatonin production matching healthy individuals, through additional mechanisms, which need to be understood, seeking to clarify whether the daily rhythm of melatonin can be restored in associated diseases.