Mapeamento dos estafilococos coagulase negativo no Hospital Universitário Antônio Pedro da Universidade Federal Fluminense, no período de 1998 a 2002

• Ano de defesa: 2006
• Autor(a) principal: Keim, Luiz Sérgio
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Programa de Pós-graduação em Ciências Médicas; Ciências Médicas
• Palavras-chave em Português: Estafilococos coagulase negativo; Medicina; Ciências Médicas; Infecção hospitalar; Resistência microbiana à drogas; Coagulase; Staphylococcus; CNPQ::CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA
• Link de acesso: https://app.uff.br/riuff/handle/1/20069

Coagulase-negative staphylococci (CoNS), one of the biggest groups of bacteria inhabiting the human skin, have been considered for decades to be a mere contaminant when isolated in culture, being, therefore, frequently neglected as etiological agents. Mapping the CoNS in Hospital Universitário Antônio Pedro (HUAP) through the retrospective evaluation of the period between January 1st, 1998 and December 31st, 2002 is the main objective of this present study. Two hundred and four CoNS strains isolated in human biological specimens have been evaluated, through automated system, from 191 patients examined in the hospital 28 external and 163 internal patients. The most frequently isolated species were Staphylococcus epidermidis (34.8%), Staphylococcus warneri (16.7%), Staphylococcus haemolyticus (16.2%), Staphylococcus simulans (10.3%), Staphylococcus sciuri (7.3%), Staphylococcus saprophyticus (2.4%), Staphylococcus hominis (2.0%), Staphylococcus capitis (2.0%), Staphylococcus xylosus (1.5%) and Staphylococcus auricularis (0.5%). In 6.4 % of the isolated CoNS, it was not possible to identify the species. Approximately 33,0% of the isolated were characterized as clinically significant; the contaminant strains and the ones that belong to the normal microbiota predominated in all attendance sectors of the hospital. Among the evaluated patients, 63 infections related to the CoNS were detected and the most frequently observed infection was the sepsis (23.7%), followed by the urinary tract infections (15.9%), the skin and soft tissues infections (15.9%), pneumonia (12.7%), the wound infections (7.9%), eye infection (6.3%), gastrointestinal infections (4.8%), meningitis (4,8%), catheters-related infections (3,2%), bones and joints infections (3.2%) and endocarditis (1.6%). Most of the infections were classified as hospital-acquired infections (57.1%). All isolated species were sensitive to vancomycin, but nine of them (4.4%) were only sensitive to this antibiotic. About 50,0% of the CoNS were resistant to oxacillin, oscillating from 35.7% in the isolated specimens from the ambulatory care up to 73.7% in patients specimens from the neonatal ICU (NICU). Staphylococcus sciuri revealed a higher level of resistance to oxacillin (86.7%). Eighty species classified as multidrug-resistant were isolated (39.2%) and were more frequently found in patients from the ICU (68.8%) and from the NICU (55.3%). Nineteen multidrug-resistant species were associated with infectious processes, from which eleven were of hospital-acquired infections