Potencial antibacteriano do extrato hidroalcoólico, frações e substâncias isoladas da própolis verde frente a patógenos multirresistentes

• Ano de defesa: 2021
• Autor(a) principal: Souza, Jonathan Messias de
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade de Franca; Brasil; Pós-Graduação; Programa de Mestrado em Ciências; UNIFRAN
• Palavras-chave em Português: Química - Substâncias naturais; Própolis verde; Bactérias multirresistentes; Artepelin C; CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA
• Link de acesso: https://repositorio.cruzeirodosul.edu.br/handle/123456789/2493

In recent years, microbial resistance to multiple drugs and the emergence of new pathogenic strains has been increasing rapidly and becoming a serious public health problem worldwide. The increase in antibiotic resistant bacteria poses a threat to clinical utility, which leads to an urgent need for studies aimed at discovering new substances with antimicrobial potential. It is known today that secondary or special plant metabolism is an inexhaustible source for the discovery of new therapeutic agents, which have attracted the attention of pharmaceutical industries, as they represent possible prototypes for the development of new drugs. Among the natural products, propolis stands out. In recent decades it has caught the attention of researchers due to its wide spectrum of applications and use in complementary and alternative medicine. The present work has as general objective to carry out the phytochemical study of the hydroalcoholic extract of green propolis, as well as to evaluate the antimicrobial potential of these metabolites against a wide range of multiresistant bacteria. The raw extract of green propolis (7:3 v/v hydroalcoholic extract), its fractions (hexane, ethyl acetate and n-butanol) and six isolated substances were tested: artepelin C, benzenepropanoic acid, baccharin, kaempferideo, acid p- coumaric and caffeic acid. The best results were obtained for the ethyl acetate fraction, which had a minimum inhibitory concentration of 62.5 µg.mL-1 , and for artelepin C, which had a minimum inhibitory concentration of 31.25 µg.mL-1 . The two best values were against the same species of bacteria (Staphyloccocus epidermidis). The results of the biological tests were in agreement with the literature. Keywords: green propolis, multi-resistant bacteria, artepillin C