Detalhes bibliográficos
Ano de defesa: |
2020 |
Autor(a) principal: |
Santana, Daiani Coelho Pereira |
Orientador(a): |
Não Informado pela instituição |
Banca de defesa: |
Não Informado pela instituição |
Tipo de documento: |
Dissertação
|
Tipo de acesso: |
Acesso aberto |
Idioma: |
por |
Instituição de defesa: |
Não Informado pela instituição
|
Programa de Pós-Graduação: |
Não Informado pela instituição
|
Departamento: |
Não Informado pela instituição
|
País: |
Não Informado pela instituição
|
Palavras-chave em Português: |
|
Link de acesso: |
https://repositorio.animaeducacao.com.br/handle/ANIMA/15182
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Resumo: |
Film forming systems present themselves as new technologies for the release of drugs in the dermatological area. The present article discusses the production of a film forming system (SFF) with Tranexamic Acid (ATX) for use after microneedling in the treatments of melasma and rosacea. It also makes the comparison of the permeation of ATX in solution that is commonly used after microneedling with SFF. SFF were produced based on poly vinyl alcohol (PVA), pectin, glycerol, poly caprolactone triol (PCL-T) and ATX. The films were characterized by scanning electron microscopy, infrared spectroscopy with fourier transform, mechanical tests, viscosity, drying time and permeation of ATX in pig skin in a Franz cell. The movies formed were transparent and without crystallization of ATX, with good elasticity and without chemical interactions between the components of the formula. The permeation of ATX in the pig skin samples that received the prior microneedling and just after the 3% solution, showed the ATX permeation 5 times greater when compared with the samples that received the SFF after the microneedling. The ATX permeation flow of the 3% solution with microneedling was 35 times greater when compared to the SFF samples without microneedling. Given these results, it can be concluded that the ATX solution commonly used in clinics to treat melasma and rosacea after microneedling, may present a higher elevation in plasma concentration, because ATX has easy permeation and in view of this, ATX can undergo systemic absorption, so SFF are good options for treatments with ATX after microneedling. |