Desenvolvimento e caracterização de um sistema formador de filme com ácido tranexâmico

Detalhes bibliográficos
Ano de defesa: 2020
Autor(a) principal: Santana, Daiani Coelho Pereira
Orientador(a): Não Informado pela instituição
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Não Informado pela instituição
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Link de acesso: https://repositorio.animaeducacao.com.br/handle/ANIMA/15182
Resumo: Film forming systems present themselves as new technologies for the release of drugs in the dermatological area. The present article discusses the production of a film forming system (SFF) with Tranexamic Acid (ATX) for use after microneedling in the treatments of melasma and rosacea. It also makes the comparison of the permeation of ATX in solution that is commonly used after microneedling with SFF. SFF were produced based on poly vinyl alcohol (PVA), pectin, glycerol, poly caprolactone triol (PCL-T) and ATX. The films were characterized by scanning electron microscopy, infrared spectroscopy with fourier transform, mechanical tests, viscosity, drying time and permeation of ATX in pig skin in a Franz cell. The movies formed were transparent and without crystallization of ATX, with good elasticity and without chemical interactions between the components of the formula. The permeation of ATX in the pig skin samples that received the prior microneedling and just after the 3% solution, showed the ATX permeation 5 times greater when compared with the samples that received the SFF after the microneedling. The ATX permeation flow of the 3% solution with microneedling was 35 times greater when compared to the SFF samples without microneedling. Given these results, it can be concluded that the ATX solution commonly used in clinics to treat melasma and rosacea after microneedling, may present a higher elevation in plasma concentration, because ATX has easy permeation and in view of this, ATX can undergo systemic absorption, so SFF are good options for treatments with ATX after microneedling.