Export Ready — 

The social brain : how social stimuli are translated into neuroendocrine signals

Bibliographic Details
Main Author: Simões, José Miguel
Publication Date: 2014
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/11957
Summary: Tese de doutoramento, Biologia (Ecofisiologia), Universidade de Lisboa, Faculdade de Ciências, 2014
id RCAP_b91112c9d24e6474c7e2668ab276faeb
oai_identifier_str oai:repositorio.ulisboa.pt:10451/11957
network_acronym_str RCAP
network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository_id_str https://opendoar.ac.uk/repository/7160
spelling The social brain : how social stimuli are translated into neuroendocrine signalsTeses de doutoramento - 2014Tese de doutoramento, Biologia (Ecofisiologia), Universidade de Lisboa, Faculdade de Ciências, 2014Animals continuously fine-tune the expression of social behaviors according to daily fluctuations on their social environment. But how does the social environment influence brain and behavior and what are the underlying physiologic, molecular and genetic mechanisms? Behavioral flexibility depends on neural plasticity of circuits underlying social behavior, which is achieved by social regulation of brain gene expression. Different neurogenomic states emerge in response to different external stimuli and switches between states are orchestrated by signaling pathways interfacing the social environment and the genotype. The goal of this thesis is to understand how social environment influences brain genomic transcription: (1) during a complex social interaction in zebrafish and (2) after stimulation with context-specific social olfactory stimuli in the Mozambique tilapia. Zebrafish, Danio rerio, has long been used as a model organism in developmental biology and genetics. Despite of their limited behavioral repertoire, the available genetic tools make it a promising model for the study of social behavior. In contrast, the Mozambique tilapia, Oreochromis mossambicus, has a rich behavioral repertoire in which visual and chemical information are conveyed to conspecifics, although having limited brain anatomy information and less genetic tools available. Our research suggests that the outcome of a single social interaction in zebrafish has consequences for subsequent behavior and significant impact on their brain transcriptome. These responses to social interactions seem to involve cognitive appraisal of stimuli, since the objective structure of the event does not trigger a genomic response but rather the appraisal the individual makes of the event. In tilapia, different chemical social cues not only affect neural activity of the olfactory epithelium but also elicit specific patterns of gene activation in brain areas related to olfactory processing. This reinforces the idea of an extensive transcriptional plasticity of teleost genomes, especially in response to rapid changes in social environment.Fundação para a Ciência e a Tecnologia (FCT, SFRH/BD/40976/2007, Programa Operacional Ciência e Inovação 2010 - POCI 2010)Oliveira, Rui F., 1966-Fonseca, Paulo Jorge Quintais Cancela da, 1958-Repositório da Universidade de LisboaSimões, José Miguel2014-09-08T14:38:49Z20142014-01-01T00:00:00Zdoctoral thesisinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10451/11957TID:101325371enginfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T13:09:31Zoai:repositorio.ulisboa.pt:10451/11957Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T02:36:27.825868Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv The social brain : how social stimuli are translated into neuroendocrine signals
title The social brain : how social stimuli are translated into neuroendocrine signals
spellingShingle The social brain : how social stimuli are translated into neuroendocrine signals
Simões, José Miguel
Teses de doutoramento - 2014
title_short The social brain : how social stimuli are translated into neuroendocrine signals
title_full The social brain : how social stimuli are translated into neuroendocrine signals
title_fullStr The social brain : how social stimuli are translated into neuroendocrine signals
title_full_unstemmed The social brain : how social stimuli are translated into neuroendocrine signals
title_sort The social brain : how social stimuli are translated into neuroendocrine signals
author Simões, José Miguel
author_facet Simões, José Miguel
author_role author
dc.contributor.none.fl_str_mv Oliveira, Rui F., 1966-
Fonseca, Paulo Jorge Quintais Cancela da, 1958-
Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Simões, José Miguel
dc.subject.por.fl_str_mv Teses de doutoramento - 2014
topic Teses de doutoramento - 2014
description Tese de doutoramento, Biologia (Ecofisiologia), Universidade de Lisboa, Faculdade de Ciências, 2014
publishDate 2014
dc.date.none.fl_str_mv 2014-09-08T14:38:49Z
2014
2014-01-01T00:00:00Z
dc.type.driver.fl_str_mv doctoral thesis
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/11957
TID:101325371
url http://hdl.handle.net/10451/11957
identifier_str_mv TID:101325371
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833601426269405184

Similar Items