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The use of nanoparticles for targeted drug delivery in non-small cell lung cancer

Bibliographic Details
Main Author: Holder, Jessica E.
Publication Date: 2023
Other Authors: Ferguson, Christopher, Oliveira, Elisabete, Lodeiro, Carlos, Trim, Carol M., Byrne, Lee J., Bertolo, Emilia, Wilson, Cornelia M.
Format: Other
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/153148
Summary: PM003/2016). Publisher Copyright: Copyright © 2023 Holder, Ferguson, Oliveira, Lodeiro, Trim, Byrne, Bertolo and Wilson.
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spelling The use of nanoparticles for targeted drug delivery in non-small cell lung cancercancerdrug deliverylung cancernanoparticlestherapeuticsOncologyCancer ResearchSDG 3 - Good Health and Well-beingPM003/2016). Publisher Copyright: Copyright © 2023 Holder, Ferguson, Oliveira, Lodeiro, Trim, Byrne, Bertolo and Wilson.Lung cancer is a global health problem affecting millions of people each year. Non-small cell lung cancer (NSCLC) is the most common form of lung cancer with various conventional treatment available in the clinic. Application of these treatments alone often results in high rates of cancer reoccurrence and metastasis. In addition, they can cause damage to healthy tissues, resulting in many adverse effects. Nanotechnology has emerged as a modality for the treatment of cancer. When used in combination with nanoparticles, it is possible to improve the pharmacokinetic and pharmacodynamic profiles of pre-existing drugs used in cancer treatment. Nanoparticles have physiochemical properties such as small size which allowing passage through challenging areas of the body, and large surface area allows for higher doses of drugs to be brought to the tumor site. Nanoparticles can be functionalized which involves modifying the surface chemistry of the particles and allows for the conjugation of ligands (small molecules, antibodies, and peptides). Ligands can be chosen for their ability to target components that are specific to or are upregulated in cancer cells, such as targeting receptors on the tumor surface that are highly expressed in the cancer. This ability to precisely target the tumor can improve the efficacy of drugs and decrease toxic side effects. This review will discuss approaches used for targeting drugs to tumors using nanoparticles, provide examples of how this has been applied in the clinic and highlight future prospects for this technology.DQ - Departamento de QuímicaLAQV@REQUIMTERUNHolder, Jessica E.Ferguson, ChristopherOliveira, ElisabeteLodeiro, CarlosTrim, Carol M.Byrne, Lee J.Bertolo, EmiliaWilson, Cornelia M.2023-05-24T22:52:51Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/other7application/pdfhttp://hdl.handle.net/10362/153148eng2234-943XPURE: 61452020https://doi.org/10.3389/fonc.2023.1154318info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:11:41Zoai:run.unl.pt:10362/153148Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:42:10.207677Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv The use of nanoparticles for targeted drug delivery in non-small cell lung cancer
title The use of nanoparticles for targeted drug delivery in non-small cell lung cancer
spellingShingle The use of nanoparticles for targeted drug delivery in non-small cell lung cancer
Holder, Jessica E.
cancer
drug delivery
lung cancer
nanoparticles
therapeutics
Oncology
Cancer Research
SDG 3 - Good Health and Well-being
title_short The use of nanoparticles for targeted drug delivery in non-small cell lung cancer
title_full The use of nanoparticles for targeted drug delivery in non-small cell lung cancer
title_fullStr The use of nanoparticles for targeted drug delivery in non-small cell lung cancer
title_full_unstemmed The use of nanoparticles for targeted drug delivery in non-small cell lung cancer
title_sort The use of nanoparticles for targeted drug delivery in non-small cell lung cancer
author Holder, Jessica E.
author_facet Holder, Jessica E.
Ferguson, Christopher
Oliveira, Elisabete
Lodeiro, Carlos
Trim, Carol M.
Byrne, Lee J.
Bertolo, Emilia
Wilson, Cornelia M.
author_role author
author2 Ferguson, Christopher
Oliveira, Elisabete
Lodeiro, Carlos
Trim, Carol M.
Byrne, Lee J.
Bertolo, Emilia
Wilson, Cornelia M.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv DQ - Departamento de Química
LAQV@REQUIMTE
RUN
dc.contributor.author.fl_str_mv Holder, Jessica E.
Ferguson, Christopher
Oliveira, Elisabete
Lodeiro, Carlos
Trim, Carol M.
Byrne, Lee J.
Bertolo, Emilia
Wilson, Cornelia M.
dc.subject.por.fl_str_mv cancer
drug delivery
lung cancer
nanoparticles
therapeutics
Oncology
Cancer Research
SDG 3 - Good Health and Well-being
topic cancer
drug delivery
lung cancer
nanoparticles
therapeutics
Oncology
Cancer Research
SDG 3 - Good Health and Well-being
description PM003/2016). Publisher Copyright: Copyright © 2023 Holder, Ferguson, Oliveira, Lodeiro, Trim, Byrne, Bertolo and Wilson.
publishDate 2023
dc.date.none.fl_str_mv 2023-05-24T22:52:51Z
2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/153148
url http://hdl.handle.net/10362/153148
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2234-943X
PURE: 61452020
https://doi.org/10.3389/fonc.2023.1154318
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 7
application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
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instacron_str RCAAP
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
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