Conjugated Nanoparticles for Solid Tumor Theranostics
| Main Author: | |
|---|---|
| Publication Date: | 2023 |
| Other Authors: | , , , , , , , , |
| Format: | Other |
| Language: | eng |
| Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Download full: | http://hdl.handle.net/10362/159718 |
Summary: | © 2023 The Authors. Published by American Chemical Society. |
| id |
RCAP_db00452702a05a29c5dbb763d93302a5 |
|---|---|
| oai_identifier_str |
oai:run.unl.pt:10362/159718 |
| network_acronym_str |
RCAP |
| network_name_str |
Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| repository_id_str |
https://opendoar.ac.uk/repository/7160 |
| spelling |
Conjugated Nanoparticles for Solid Tumor TheranosticsUnraveling the Interplay of Known and Unknown FactorsCancerCellsDrug deliveryMetal nanoparticlesNanoparticlesSDG 3 - Good Health and Well-being© 2023 The Authors. Published by American Chemical Society.Cancer diagnoses have been increasing worldwide, and solid tumors are among the leading contributors to patient mortality, creating an enormous burden on the global healthcare system. Cancer is responsible for around 10.3 million deaths worldwide. Solid tumors are one of the most prevalent cancers observed in recent times. On the other hand, early diagnosis is a significant challenge that could save a person's life. Treatment with existing methods has pitfalls that limit the successful elimination of the disorder. Though nanoparticle-based imaging and therapeutics have shown a significant impact in healthcare, current methodologies for solid tumor treatment are insufficient. There are multiple complications associated with the diagnosis and management of solid tumors as well. Recently, surface-conjugated nanoparticles such as lipid nanoparticles, metallic nanoparticles, and quantum dots have shown positive results in solid tumor diagnostics and therapeutics in preclinical models. Other nanotheranostic material platforms such as plasmonic theranostics, magnetotheranostics, hybrid nanotheranostics, and graphene theranostics have also been explored. These nanoparticle theranostics ensure the appropriate targeting of tumors along with selective delivery of cargos (both imaging and therapeutic probes) without affecting the surrounding healthy tissues. Though they have multiple applications, nanoparticles still possess numerous limitations that need to be addressed in order to be fully utilized in the clinic. In this review, we outline the importance of materials and design strategies used to engineer nanoparticles in the treatment and diagnosis of solid tumors and how effectively each method overcomes the drawbacks of the current techniques. We also highlight the gaps in each material platform and how design considerations can address their limitations in future research directions.Centre for Toxicogenomics and Human Health (ToxOmics)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNChavda, Vivek PBalar, Pankti CNalla, Lakshmi VineelaBezbaruah, RajashriGogoi, Niva RaniGajula, Siva Nageswara RaoPeng, BerneyMeena, Avtar SConde, JoãoPrasad, Rajendra2023-11-08T22:08:35Z2023-10-172023-10-17T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/other31application/pdfhttp://hdl.handle.net/10362/159718eng2470-1343PURE: 75498430https://doi.org/10.1021/acsomega.3c05069info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-05-26T01:40:56Zoai:run.unl.pt:10362/159718Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:46:18.151682Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Conjugated Nanoparticles for Solid Tumor Theranostics Unraveling the Interplay of Known and Unknown Factors |
| title |
Conjugated Nanoparticles for Solid Tumor Theranostics |
| spellingShingle |
Conjugated Nanoparticles for Solid Tumor Theranostics Chavda, Vivek P Cancer Cells Drug delivery Metal nanoparticles Nanoparticles SDG 3 - Good Health and Well-being |
| title_short |
Conjugated Nanoparticles for Solid Tumor Theranostics |
| title_full |
Conjugated Nanoparticles for Solid Tumor Theranostics |
| title_fullStr |
Conjugated Nanoparticles for Solid Tumor Theranostics |
| title_full_unstemmed |
Conjugated Nanoparticles for Solid Tumor Theranostics |
| title_sort |
Conjugated Nanoparticles for Solid Tumor Theranostics |
| author |
Chavda, Vivek P |
| author_facet |
Chavda, Vivek P Balar, Pankti C Nalla, Lakshmi Vineela Bezbaruah, Rajashri Gogoi, Niva Rani Gajula, Siva Nageswara Rao Peng, Berney Meena, Avtar S Conde, João Prasad, Rajendra |
| author_role |
author |
| author2 |
Balar, Pankti C Nalla, Lakshmi Vineela Bezbaruah, Rajashri Gogoi, Niva Rani Gajula, Siva Nageswara Rao Peng, Berney Meena, Avtar S Conde, João Prasad, Rajendra |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Centre for Toxicogenomics and Human Health (ToxOmics) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Chavda, Vivek P Balar, Pankti C Nalla, Lakshmi Vineela Bezbaruah, Rajashri Gogoi, Niva Rani Gajula, Siva Nageswara Rao Peng, Berney Meena, Avtar S Conde, João Prasad, Rajendra |
| dc.subject.por.fl_str_mv |
Cancer Cells Drug delivery Metal nanoparticles Nanoparticles SDG 3 - Good Health and Well-being |
| topic |
Cancer Cells Drug delivery Metal nanoparticles Nanoparticles SDG 3 - Good Health and Well-being |
| description |
© 2023 The Authors. Published by American Chemical Society. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-11-08T22:08:35Z 2023-10-17 2023-10-17T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/other |
| format |
other |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/159718 |
| url |
http://hdl.handle.net/10362/159718 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2470-1343 PURE: 75498430 https://doi.org/10.1021/acsomega.3c05069 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
31 application/pdf |
| dc.source.none.fl_str_mv |
reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia instacron:RCAAP |
| instname_str |
FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia |
| instacron_str |
RCAAP |
| institution |
RCAAP |
| reponame_str |
Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| collection |
Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| repository.name.fl_str_mv |
Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia |
| repository.mail.fl_str_mv |
info@rcaap.pt |
| _version_ |
1833596948165165056 |