Avaliação dos efeitos de triclosan, triclocarban e suas misturas em diferentes bioindicadores

• Ano de defesa: 2019
• Autor(a) principal: Gomes, Monike Felipe
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso embargado
• Idioma: por
• Instituição de defesa: Universidade Tecnológica Federal do Paraná; Curitiba; Brasil; Programa de Pós-Graduação em Ciência e Tecnologia Ambiental; UTFPR
• Palavras-chave em Português: Agentes antiinfecciosos; Cosméticos; Testes de toxicidade; Toxicologia ambiental; Ecotoxicologia e qualidade ambiental; Tecnologia ambiental; Anti-infective agents; Cosmetics; Toxicity testing; Environmental toxicology; Ecotoxicology and environmental quality; Green technology; CNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA::TOXICOLOGIA; Ciências Ambientais
• Link de acesso: http://repositorio.utfpr.edu.br/jspui/handle/1/4310

Triclosan (TCS) and triclocarban TCC are common antimicrobials applied in personal care products such as soaps, shampoos and toothpastes. These products are largely used worldwide and introduced to aquatic environments, reaching concentrations of ng L-1 and µg L-1. According to the literature, TCS and TCC can be harmful to aquatic organisms, showing acute affects under 1 mg L-1, however few studies show their effects at environmental concentrations. In this study ecotoxicity of triclosan and triclocarban were analyzed in two different approaches. One considering environmental concentrations of TCS, TCC and their mixture using three trophic levels (D. subspicatus, D. magna and R. quelen) and the other considering mixture interactions between these compounds though reference models evaluating acute endpoints to D. magna. At environmental concentrations, R. quelen embryos presented morphological effects and enzyme alterations to catalase, acetylcholinesterase and superoxide dismutase. To D.magna, it was evaluated reproduction and biochemical endpoints in multigenerational exposure. To this organism late reproduction and biochemical alterations related to oxidative stress were observed. On the second part of this work TCS and TCC mixtures were evaluated though acute assay where it was possible to fit its interactions on CA reference model with DR deviation through MIXTOX tool.