Detalhes bibliográficos
| Ano de defesa: |
2010 |
| Autor(a) principal: |
LEMOS, Ana Janaina Jeanine Martins de
 |
| Orientador(a): |
TEIXEIRA, Valéria Wanderley |
| Banca de defesa: |
SIQUEIRA, Herbert Álvaro Abreu de,
MAIA, Frederico Celso Lyra |
| Tipo de documento: |
Dissertação
|
| Tipo de acesso: |
Acesso aberto |
| Idioma: |
por |
| Instituição de defesa: |
Universidade Federal Rural de Pernambuco
|
| Programa de Pós-Graduação: |
Programa de Pós-Graduação em Biociência Animal
|
| Departamento: |
Departamento de Morfologia e Fisiologia Animal
|
| País: |
Brasil
|
| Palavras-chave em Português: |
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| Palavras-chave em Inglês: |
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| Área do conhecimento CNPq: |
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| Link de acesso: |
http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/4492
|
Resumo: |
The use of microbial insecticides as an alternative to the use of synthetic insecticides has been increased due to the low environmental persistence and security to non-target organisms such as mammals, birds, amphibians and reptiles. However, experiments showed that the protein toxins of the bacterium Bacillus thuringiensis cause hypersensitivity in some organs such as kidneys, liver and lungs and differently interfere in male and female rats. However, few studies have shown the effects of sublethal doses of synthetic insecticides about female reproductive system and almost no reports on the effects of biological insecticides in humans, mainly related to reproductive histophysiologies. So, decided to test hypothesis whether the administration of pesticides XenTari® WG (Bacillus thuringiensis subsp. Aizawai) and deltamethrin (Decis® 25CE), at concentrations that do not show clinical signs of maternal intoxication, possibly interfere with blastocyst-endometrial interaction and organs maternal albino rats. We used 70 albino rats, Rattus norvegicus albinos randomly divided into 14 groups each consisting of five animals.The animals were subjected to sublethal concentrations of synthetic insecticide, in doses of 1, 2 and 4 mg/kg of deltamethrin-(Decis® 25CE) and biological insecticide in doses of 18.5, 185 and the 370mg/100g XenTari® WG. The results showed that the rats undergone highest doses of both insecticides showed significant reduction in the number and histopathological changes of sites deployed, characterized by the presence of vacuolated trophoblast cells, cytotrophoblasts rare, leukocyte infiltration, degeneration in the region decidua, and presence of blood in the uterine lumen. Histochemically the uterus’ decidua rats showed more fibrous, especially in rats treated with highest dosage of the biological insecticide. In the mother's organs were observed histopathological changes in kidneys showing mainly hemosiderin deposition, necrosis and vacuolar degeneration of convoluted tubules and collecting ducts, and glomerulonephritis; liver, reaction of Kupffer cells and vacuolar degeneration of hepatocytes; lung, peribronquiolite, perivasculitis and multifocal pneumonia. Thus, it is concluded that sublethal doses of insecticide XenTari® produces qualitative and quantitative changes in endometrial-blastocyst interaction, and maternal organs similarly to sublethal doses of deltamethrin, usually involving inflammatory processes, including undermining the process of deployment albino rats. |
