Influência do extrato de chá verde na remodelação cardíaca após o infarto agudo do miocárdio

• Ano de defesa: 2013
• Autor(a) principal: Lustosa, Beatriz Helena Borges [UNESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Estadual Paulista (Unesp)
• Palavras-chave em Português: Chá verde - Uso terapêutico; Infarto do miocárdio - Estudos experimentais; Rato como animal de laboratorio; Remodelação ventricular; Green tea
• Link de acesso: http://hdl.handle.net/11449/108584

One mechanism that explains how acute myocardial infarction develops into heart failure is called ventricular remodeling. Among the many biochemical changes associated with the process stands oxidative stress. The regular consumption of green tea (GT) is associated with health benefits due to its properties such as antioxidant, anti-inflammatory, antiapoptotic, antiproliferative, antimutagenic. These are attributed to catechins, its bioactive compound. Therefore, it is possible that GT extract mitigate some parameters involved in cardiac remodeling. The objective of this study was to assess whether the green tea extract attenuates cardiac remodeling after acute myocardial infarction. For both, male Wistar rats were allocated in 4 groups: control (C-28 sham); green tea extract (GT-32 sham and GT); infarction group (MI-25 infarcted animals controls); infarction and green tea extract (IGT-26 infarcted animals and GT). To start the treatment an initial echocardiography was performed five days after the myocardial infarction, from a homogeneous division of the animals, considering the size of the infarction greater than 35%. At the end of three months these animals were studied by echocardiography, morphometry, biochemical enzyme of the oxidative stress, energy metabolism, lipid profile, tissue inhibitor of metalloproteinase (TIMP-1) and zymography for activity of metalloproteinases (MMP-2 and MMP-9). The results showed an increase in left ventricular diastolic diameter by body weight, left ventricular systolic diameter by body weight and left atrial diameter by body weight in groups with MI, but there was attenuation in IGT. The deceleration time of the E wave was reduced in MI, which was not observed in IGT, with a value similar to GT group. GT extract also normalized the activities of antioxidant enzymes superoxide dismutase and catalase in the IGT group, when compared to MI. Regarding energy metabolism, the IGT group showed increased ...