O bloqueio da autofagia induzida por drogas aumenta a imunogenicidade das células de câncer colorretal

• Ano de defesa: 2020
• Autor(a) principal: Zamame Ramirez, Jofer Andree
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Estadual Paulista (Unesp)
• Palavras-chave em Português: Autofagia; Câncer colorretal; Quimioterapia; Células dendríticas; Células T citotóxicas
• Link de acesso: http://hdl.handle.net/11449/202326

Dendritic cells (DCs) are a heterogenous population of immune cells responsible for antigens processing and presentation to T lymphocytes. They are divided in several subsets with distinct phenotypic and functional features and can be found in the blood, skin, mucosa, lymphoid and non-lymphoid tissues. DCs have a central role in the development of an immune response both against infectious and malignant diseases, and in the regulation of autoimmune and allergic responsiveness. Considering that DC function is usually impaired in cancer patients, several authors have proposed the development of DC-based antitumor therapeutic vaccines, aiming to restart the immune system and improve the CD4+ and CD8+ lymphocytes responsiveness against cancer. In the present review, we overviewed the DCs’ biology and their role in the antitumor immunity, the distinct protocols for preparing DC-based vaccines, and the clinical trials involving different types of cancer, evidencing the feasibility of this approach to personalize the anticancer therapy.