Investigação da ação quelante e antioxidante da N-acetilcisteína sobre o cádmio

• Ano de defesa: 2018
• Autor(a) principal: Caz, Priscila Da
• Orientador(a): Itinose, Ana Maria
• Banca de defesa: Itinose, Ana Maria , Marek, Carla Brugin , Quinaia, Sueli Pércio
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Estadual do Oeste do Paraná; Cascavel
• Programa de Pós-Graduação: Programa de Pós-Graduação em Ciências Farmacêuticas
• Departamento: Centro de Ciências Médicas e Farmacêuticas
• País: Brasil
• Palavras-chave em Português: Antídoto; Enzimas antioxidantes; Estresse oxidativo; Intoxicação crônica; Metais pesados; GFAAS
• Palavras-chave em Inglês: Antidote; Antioxidant enzymes; Oxidative stress; Chronic intoxication; Heavy metals; GFAAS
• Área do conhecimento CNPq: CIENCIAS DA SAUDE::FARMACIA
• Link de acesso: http://tede.unioeste.br/handle/tede/3878

Cadmium (Cd) is a heavy metal seen as an important pollutant for man. It is widely distributed in nature and also presents in cigarette and in production line of various industrial sectors. It has carcinogenic and toxic effects on organs such as brain, lung, kidney and liver due its excessive production of reactive oxygen species (ROS). N-acetylcysteine (NAC) is a mucolytic agent that exhibits properties as antioxidant and chelating agent due its ability to reduce reactive oxygen species and provide chelating sites for metals. Therefore, NAC is effective in detoxification process. This study has validated a method for cadmium quantification in plasma of rats by atomic absorption spectrometry with electrothermal atomization in graphite furnace (GFAAS). It presented satisfactory and approved results. The protective action of NAC on lipid peroxidation in renal tissue of rats submitted to cadmium intoxication was also investigated. The results showed that NAC presents protective effect to reverse lipid peroxidation suggesting that it preserves renal tissue damage caused by cadmium.