What is the relationship between HIV and skin wound healing process? A systematic review of clinical evidence
| Ano de defesa: | 2022 |
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| Autor(a) principal: | |
| Orientador(a): | |
| Banca de defesa: | |
| Tipo de documento: | Dissertação |
| Tipo de acesso: | Acesso aberto |
| Idioma: | eng |
| Instituição de defesa: |
Universidade Federal de Viçosa
Biologia Celular e Estrutural |
| Programa de Pós-Graduação: |
Não Informado pela instituição
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| Departamento: |
Não Informado pela instituição
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| País: |
Não Informado pela instituição
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| Palavras-chave em Português: | |
| Link de acesso: | https://locus.ufv.br//handle/123456789/30766 https://doi.org/10.47328/ufvbbt.2023.071 |
Resumo: | Introduction: The steady rise in the number of people living with HIV (PLHIV) all over the world confirms that HIV/AIDS is a notable global pandemic. PLHIV often have cutaneous wound infection with grave consequences, including prolonged hospitalization stay and further weakening of the immune system. Although it is known that HIV interferes with the time of the wound healing process, what remains poorly understood are the main pathways activated in this process and the relationship between these pathways, and the delay in the closure of skin wounds in infected patients. Aim: This systematic review aims to analyze the current evidence regarding the influence of HIV on the cellular pathways activated during the closure of skin wounds in patients infected compared to uninfected healthy humans. Methods: A structured search on the Pubmed/Medline, Scopus, and Web of Science databases were used to retrieve articles based on our eligibility criteria. The screening of articles that met the inclusion criteria was done using the PRISMA strategy and the risk of bias for all selected studies was assessed with the SYRCLE’s tool. Results: A total of twelve (12) studies involving HIV seropositive patients were selected and reviewed. HIV was shown to slow the process of wound healing when compared to the control. A low CD4 + count correlated with a worse healing time and increased the chance of wound infections. Despite the administration of antibiotics (n=4, 33.33, especially Cephazolin (n=2, 17%)), wound healing time in HIV+ patients were slower compared to healthy individuals and no antibiotic showed a direct influence on the wound healing process. Conclusion: Wound closure is impaired in HIV+ patients, probably by the release of extracellular vesicles with HIV-derived components that can modulate host immunity and promote the severity of the infection, especially CD4+, compromising the wound healing process. Thus, this study highlights the importance of preserving the immune system of HIV- positive patients to maintain a good pattern of healing, especially for skin wounds. This study is registered on the PROSPERO platform (CRD42021265199). Keywords: Wound healing. HIV. Skin. Humans. CD4 + .5 |