Influência do enxerto omental livre autógeno no tratamento de lesão óssea induzida experimentalmente no osso rádio de coelho (Oryctolagus cuniculus familiaris)

• Ano de defesa: 2018
• Autor(a) principal: Borges, Leandro William
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Uberlândia; Brasil; Programa de Pós-graduação em Ciências Veterinárias
• Palavras-chave em Português: Enxerto omental; Bone regeneration; Células Gigantes; Ostectomia; Regeneração óssea; Giant cells; Ostectomy; Omental graft; Veterinária; Coelhos; Ossos enxerto; CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA::CLINICA E CIRURGIA ANIMAL::TECNICA CIRURGICA ANIMAL
• Link de acesso: https://repositorio.ufu.br/handle/123456789/24339; http://dx.doi.org/10.14393/ufu.di.2019.1214

Abstract - Bone tissue is essential in locomotion, internal organs protection and in the hematopoietic and immunological systems cells production of animals. Lesions in this tissue, especially in pet animals, usually occur due to trauma. Fractures have been widely discussed in veterinary orthopedics, mainly regarding treatment methods, recovery time and complications. An option in the treatment of bone lesions are the grafts. with aim to study the influence of the autogenous free omental graft on the repair of bone defect, 32 male, uncastrated New Zealand rabbits aged between 6 and 7 months were divided into two groups (GI control and GII treated with free omental graft) with 16 animals each. 1 cm Segmental bone defects were surgically criated in the middle third of the right Radio. At the same surgical procedure, the celiotomy was also performed to obtain the graft from the omentum, including the GI animals. The GII animals had bony defects covered with autogenous free omental graft. Immediately after the surgeries and at 45 and 90 days, the animals had their respective forearms radiographed for later images evaluation. Blood samples were also collected for the measurement of bone alkaline phosphatase on days 0 (before surgery), 45 and 90 (after surgery). Half of the animals in each group were euthanized at 45 days and 90 days, respectively, to collect samples from the previously injured area, aiming the preparation of histological laminae. There was no difference in bone alkaline phosphatase serum levels between GI and GII at 45 and 90 days (p = 0.42), nor at the radiographic evaluation comparing the groups (p = 0.99). Histologically, no difference was also observed in the regeneration process of bone defects between GI and GII, except for the presence of residues from the omental graft under absorption, suggesting a foreign body reaction. The autogenous free omental graft, on treatment of 1 cm extension bone defects in New Zealand rabbit Radio, did not influence the bone regeneration process.