Desordens tireoideanas em pacientes portadores de Hepatite C

• Ano de defesa: 2009
• Autor(a) principal: Santos, Sandra Regina Xavier
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Uberlândia; BR; Programa de Pós-graduação em Ciências da Saúde; Ciências da Saúde; UFU
• Palavras-chave em Português: Interferon alfa; Alpha interferon; Ribavirin; Hepatitis C; Thyroid; Hypothyroidism; Ribaverina; Hepatite C; Tireóide; Hipotiroidismo; Tireóide - Doenças; CNPQ::CIENCIAS DA SAUDE
• Link de acesso: https://repositorio.ufu.br/handle/123456789/12650

Alpha Interferon and Ribavirin are the drugs of choice for treating Hepatitis C, but may trigger thyroid disorders as a major complication. Several studies have shown a prevalence vary (1% to 35%) of this association influenced by geographical distribution, genetics and iodine intake of the population. The objective of this study was to analyze the thyroid disorders in carrying patients of Hepatitis C in treatment or not with alpha Interferon and Ribavirin. We evaluated the frequency and pattern of thyroid disorders in 25 patients with hepatitis C in treatment with alpha interferon and Ribavirin (G1), 62 patients with Hepatitis C without treatment (G2) and 82 patients without Hepatitis C (control group) measuring TSH, antiperoxidase antibodies (anti-TPO) and antitireoglobulina (ATG). The hypothyroidism was more frequent in the carrying patients of Hepatitis C in treatment (36%), while the frequency of thyroid antibodies was not different in the three studied groups respectively (12% in G1; 8,06% in G2 and 17,07% in control group). It was not possible to demonstrate the biggest prevalence of Autoimmune Thyroid Disease in carrying patients of Hepatitis C in treatment with alpha Interferon and Ribavirin; even so the hypothyroidism has been more frequent in this group. Thus, carrying patients of Hepatitis C submitted to this treatment must make tracking of the thyroid dysfunction, as already considered for some authors.