Qualidade de vida, depressão e ansiedade em mulheres com doença trofoblástica gestacional

• Ano de defesa: 2020
• Autor(a) principal: Grecco, Gabriela Menossi [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Gestational Trophoblastic Disease; Quality Of Life; Depression; Anxiety; Doença Trofoblástica Gestacional; Qualidade De Vida; Depressão; Ansiedade
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=9793508; https://hdl.handle.net/11600/64895

Objective: To assess quality of life, depression and anxiety in women with gestational trophoblastic disease (GTD) before remission (active disease) of the hydatidiform mole (HM) or gestational trophoblastic neoplasia (GTN) and after remission. Methods: This longitudinal study was conducted among 51 women, assessing aspects of quality of life and psychological impacts using validated questionnaires: World Health Organization Quality of Life (WHOQOL-bref), Beck Depression Inventory (BDI) and State-Trait Anxiety Inventory. (STAI-Y). Results: The study highlights that quality of life (QoL) was “regular”, 68.6% were classified as “absence of depression”, 13.7% as “depression” and 17.6% as “dysphoria” in women with active disease. As for anxiety, the score corresponded to “medium-high anxiety” in both trait-anxiety and state -anxiety. After remission of GTD there was a significant improvement in all variables. In QoL, the improvement was evident in the total (p = 0.023), physical (p = 0.003) and satisfaction with health (p = 0.006) domains, although they were classified as “regular”. As for depression, there was also a significant improvement (p <0.001), as well as in the anxiety-trait (p = 0.003) and state anxiety (p <0.001) inventory score. Conclusion: Regarding QoL, depression and anxiety, no significant differences in results were found in relation to women with active disease. The results were similar, regardless of whether women were waiting remission of HM or with a diagnosis of GTN. In the analysis regarding times T1 and T2 (active disease and disease in remission), we concluded that there was a improvement in QOL, absence of depressive symptoms and anxiety after disease remission.