Desenvolvimento de nanopartículas lipídicas sólidas contendo filtro solar orgânico e óleo vegetal da flora brasileira

• Ano de defesa: 2017
• Autor(a) principal: Bim, Antonio Vinicius Kosiski [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo
• Palavras-chave em Português: Solid lipid nanoparticle; Octyl methoxycinnamate; Sun protection factor; Pampa; Franz cell; Nanopartículas lipídicas sólidas; Metoxicinamato de octila; Fator de proteção solar; Célula de franz
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=5503946; http://repositorio.unifesp.br/handle/11600/50456

The use of sunscreen products is widely promoted by schools, government agencies and health-related organizations to minimize sunburn and skin damage, which can lead to skin cancer. In this study, we developed stable solid lipid nanoparticles (SLN) containing the UV chemical filter octyl methoxycinnamate (OMC), associated or not with wheat germ oils (Triticum sativum Lank) and urucum oil (Bixa orellana L.) using emulsification techniques, high shear dispersion and high pressure homogenization. It was possible to obtain nanoparticles with adequate dimensions and stability for application in sunscreen formulations. Ex vivo tests (skin diffusion) did not show significant permeation, whereas in vitro tests (PAMPA) demonstrated that SLNs are able to diffuse through the lipid layer without altering its size, suggesting stability in the skin. In vitro solar protection factor (SPF) studies indicate that when 20% of the OMC was replaced by urucum oil, there was no reduction in SPF, suggesting that a decrease in the amount of chemical filter may be a viable alternative to an effective sunscreen, in combination with oils as urucum, rich in antioxidants. The results corroborate a strong trend to increase the safety of sun protection products by reducing the use of ultraviolate (UV) chemical filters producing formulations with lower concentrations of OMC while maintaining SPF. Further investigations of in vivo SPF are required to evaluate the suitability of these formulations for human use.