A Influência do bilinguismo na doença de Alzheimer

• Ano de defesa: 2018
• Autor(a) principal: Paulavicius, Andrea Muner [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Alzheimer disease; Bilinguism; Cognitive reserve; Systematic review; Doença de Alzheimer; Bilinguismo; Reserva cognitiva; Revisão sistemática
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=6913763; https://repositorio.unifesp.br/handle/11600/52508

Background: Alzheimer's disease is a neurodegenerative disease characterized by the loss of cognitive functions. Bilingualism maybe one factor contributing to cognitive reserve and delay in symptom to onset. Objectives: To assess effect of bilingualism compared with monolingualism in Alzheimer's disease. Methods: Systematic review of the literature of observational studies comparing bilingualism versus monolinguals in patients with Alzheimer’s disease. We searched the databases: The Cochrane Central Register of Controlled Trials, MEDLINE, Embase and LILACS. The quality of each included study was assessed using the NewcastleOttawa Scale. Two reviewers independently extracted data and bias risk assessment. The quality of the evidence was evaluated by the Grading of Recommendations Assessment, Development and Evaluation. Results: Eight studies were included in the systematic review. The metaanalysis showed there was no difference between monolinguals and bilinguals group in the outcomes: Cognitive impairment level measured through MiniMental State Examination at the time of assessment (MD = 0. 20; 95%CI: 0.99,1.40) ; at the age of diagnosis (MD = 0.46; 95%CI: 0.21, 1.14), age of diagnosis of Alzheimer's disease (MD = 2.61; 95%CI: 5.77, 0.55); cognitive and functional performance measured through Clinical Dementia Rating ( MD = 0. 11; 95%CI: 0.06, 0.27), and Behavioral Neurology Assessment (MD=6.35; 95%CI:0.17,12.88). The analysis showed that bilingual patients exhibited symptoms of dementia later than a comparable group of monolingual patients (MD 5. 57; 95%CI: 3.43, 7. 70). The evidence found was low and very low quality. Conclusion: Although this systematic review did not show difference between bilingual and monolingual group in most outcomes analyzed, the available data s how that the onset of symptoms in Alzheimer's disease was later in the bilingual group compared with the monolingual.