Avaliação de marcadores cardíacos em pacientes com câncer de mama recebendo tratamento antineoplásico: uma revisão sistemática

• Ano de defesa: 2021
• Autor(a) principal: Soares, Tiago Nunes Da Silva [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Cardiac Markers; Breast Cancer; Chemotherapy; Cardiotoxicity; Biomarkers; Marcadores Cardíacos; Câncer De Mama; Quimioterapia; Cardiotoxicidade; Biomarcadores
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=11207722; https://repositorio.unifesp.br/handle/11600/68096

Cardiac markers are important biochemical indicators in the diagnosis of heart and coronary insufficiency, and it is through them that we can measure the damage to cardiac fibers resulting from these diseases. Recent research has shown that the levels of these biomarkers are altered in individuals who have neoplasms under chemotherapy treatment without these patients having any clinical manifestations. It is also known that one of the main adverse effects in treatment with antineoplastic agents is cardiotoxicity. The objective of this work was to carry out a systematic review of the main cardiac biomolecular markers in scientific publications bases and to verify how their levels present in individuals with breast cancer, as well as to analyze the influence of antineoplastic treatment in the circular levels of these markers as a resulting from the effects of cardiac damage on patient therapy and which are good predictors of cardiovascular diseases related to chemotherapy treatment. For this, three databases were used, namely: Medline, Lilacs and Cochrane. In these databases, systematic searches of publications were carried out between the years 2010 and 2020 using the descriptors "Mesh" or the equivalent in the chosen database. After searching the scientific publication in the databases, the duplicates were removed and the other publications were selected against the following eligibility criteria: studies only with breast cancer patients who received any type of chemotherapy treatment; studies that evaluated the following cardiac biomarkers: Troponin, pro-BNP / NT-pro-BNP, myoglobin, CK-MB, fibrinogen, and D-dimer; publications which the study design were clinical trials or observational studies; articles available in English, Spanish or Portuguese language. At the end, 31 published articles were obtained for analysis in which cardiac markers ultra-sensitive Troponin I and T, myoglobin, and NT-proBNP showed to be the best predictors of cardiotoxicity for breast cancer patient under chemotherapy.