Avaliação do marcador tumoral c-met/HGF no prognóstico do câncer colorretal através da técnica da imuno-histoquímica

• Ano de defesa: 2006
• Autor(a) principal: Oliveira, Antonio Talvane Torres de [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: c-met/HGF; Marcadores de tumor; Neoplasias colorretais; Marcadores biológicos de tumor; Tumor markers, biological; Colorectal neoplasms
• Link de acesso: http://repositorio.unifesp.br/handle/11600/9131

Objective: To evaluate the prognostic meaning of the c-met/HGF tumoral marker, through the immunohistochemical technique, in patients with colorectal adenocarcinoma who have been subjected to surgical treatment. Methods: A retrospective descriptive study of 286 patients with colorectal adenocarcinoma, who have been seen and operated at Barretos Cancer Hospital, from 1993 to 2002. The tissular expression of the tumoral marker was evaluated using the cmet/ HGF anti-protein monoclonal antibody through the estreptavidin-biotinperoxidase technique. The positivity analysis of the marker was semiquantitative, and plate reading was independently carried out by three pathologists with no previous knowledge on clinical and histopathological data of patients. Results: Out of a total of 286 patients, the marker was positive in 236 (78.8%) and negative in 50 (21.2%). It was found statistically significant difference (p=0.004) between stages l and lV, at global life span (p=0.009), and at cancer mortality rate (p=0.022); however, there was no association between the marker and recurrence (p=0.89) or the marker and disease-free period (p=0.91). Conclusion: c-met/HGF has shown significance as a tumoral marker in stages l and lV of the disease, at global life span, and at cancer mortality rate; however, there was no significant association with the remaining prognostic variables that have been studied.