Avaliação dos fatores prognósticos clínicos, laboratoriais, cirúrgicos, anatomopatológicos e imuno-histoquímicos no carcinoma de vesícula biliar ressecado

• Ano de defesa: 2014
• Autor(a) principal: Costa, Sergio Renato Pais [UNIFESP]
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: biliary tract neoplasms; adenocarcinoma; biological markers of tumor antigen cd and prognosis; neoplasias vias biliares; marcadores biológicos de tumor; antígeno cd e prognóstico
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=1301025; https://repositorio.unifesp.br/handle/11600/46315

Aims: To evaluate prognostic factors for survival in cases of gallbladder adenocarcinoma. Method: Clinical, laboratory, surgical, anatomopathological and, immunohistochemical (tissue expression of the proteins P53, E-cadherin, Cox-2 and EGFR) data on a series of 42 resected patients due to gallbladder adenocarcinoma from January 1995 to January 2006 were gathered. The sample comprised 7 men and 35 women. The median age 71 years (range: 35-87 years). The lesion distribution according to the TNM-AJCC classification was: T1 (n = 2), T2 (n = 5), T3 (n = 31) and T4 (n = 4). Twenty patients underwent curative resection (R0), while 22 had palliative surgery (R1-R2). These results were correlated with the final prognosis and with the patients’ survival. Uni and multivariate statistical analyses were conducted using the PASW statistical software, version 17 (SPSS Inc., 2009) for Windows; p < 0.05 was considered to be statistically significant. The survival analysis was performed using Kaplan-Meier curves, and the outcome from comparisons between the curves was calculated using the log-rank test. Results: The estimated five-year survival was 26%, while the median was 8 months. Multivariate analysis identified four independent prognostic factors: serum albumin (< 3.0 ng/ml), gallbladder perforation, tumor necrosis and tissue overexpression of the protein EGFR. Conclusion: The final prognosis in the gallbladder cancer cases was affected by serum albumin, perforation of the surgical specimen, tumor necrosis and tissue overexpression of the protein EGFR.