Bilirrubina transcutânea em recém-nascidos pré-termo tardio, termo precoce e a termo em aleitamento materno exclusivo na primeira semana de vida

• Ano de defesa: 2010
• Autor(a) principal: Pereira, Dilma Carvalho [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Aleitamento materno; Hiperbilirrubinemia; Recém-nascidos; Icterícia
• Link de acesso: https://repositorio.unifesp.br/handle/11600/9143

Background. Since most of newborn infants are fully breastfed in the first week of life, it is important to understand the behavior of physiological bilirubin values to guide mothers during hospital stay and follow them up after hospital discharge. Objective: To determine the increase and decrease of transcutaneous bilirubin (TcB) in late-preterm infants, early term and term newborns fully breastfed in the first week of life. Method: A prospective cohort study with 210 healthy, fully breastfed neonates born from March/09-March10, with the following criteria: 35-39 weeks of gestation, birth weight >2000g, Apgar 5 min >7, without any congenital malformation or hemolytic disease. All were at rooming-in before 6 hours of life. Each newborn had sternum TcB (JM 103 Minolta) and body weight measured at 24, 48, 96 , 144 and 192 hours of life. The TcB was considered until initiation of phototherapy, according to AAP 2004. TcB mean estimates were compared by ANOVA repeated measures between late preterm (n=60), early term (n=60), and full term (n=90) newborn infants. Maternal and neonatal characteristics were compared between groups by one-way ANOVA, Kruskal Wallis, X2, and Fisher test (significant p<0.05). Results: The 3 groups were similar regarding to: maternal age 23+7 years, first gestation 54%, hypertension/diabetes 12%, vaginal delivery 70%, male 49%, ABO incompatibility 10%, breastfed in the 1st h after birth - 57%, and the highest weight loss 5.9&#61617;2.0% (maximum 11%) at 48th hour. However, phototherapy was applied in 22% late pre-term, 5% early term, and 1% of term neonates (p<0.001). BTc mean estimates in PTT, TP e T were, respectively, at 24h – 4.5; 3.9; 3.1 mg/dL (p=0,037), at 48h – 7.4; 6.3; 4.7 mg/dL (p<0.001), at 96h – 7.8; 7.0; 4.4 mg/dL (p<0.001), and at 192h – 4.9; 4.9 and 2.5 mg/dL (p<0,001). Late preterm and early term infants had similar TcB levels, around 2.0-3.0 mg/dL higher than in term newborns until 192 hours of life. A TcB decrease at 0.02-0.03 mg/dL/hour was found between 96 and 192h of life in LPT and ET. Late preterm and early term patients had similar TcB levels, around 2.0- 3.0 mg/dL higher than in term newborns until 192 hours of life. A TcB decrease 0.02-0.03 mg/dL/hour was found between 96 and 192h of life in the 3 groups. Conclusion: Fully breastfed late preterm and early term newborn babies have similar increase and decrease of TcB levels, but higher than in term newborn infants, in the first week of life.