Eficácia da suplementação nutricional de nutrientes componentes da membrana neuronal na cognição de pacientes com comprometimento cognitivo leve

• Ano de defesa: 2018
• Autor(a) principal: Coca, Debora Santos [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Nutritional supplementation; Cognitive impairment; Cognition; Disfunção cognitiva; Comprometimento cognitivo; Suplementação alimentar; Cognição
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=6722236; https://repositorio.unifesp.br/handle/11600/52173

Objectives: To verify if the supplementation with nutrients forming the neuronal membrane can improve or maintain the cognition of individuals with Mild Cognitive Impairment (CCL) and if there is a relationship between nutritional status and cognition. Methods: A prospective, randomized, sevenmonth study was conducted at the Behavioral Neurology Outpatient Clinic of the Federal University of São Paulo. The sample consisted of 60 patients diagnosed with CCL according to the Petersen criteria, divided into two groups: 30 participants in the control group and 30 participants in the supplement group. Participants were monitored once a month for seven months in relation to nutritional status, through anthropometric and cognition assessment, using a battery of specific neuropsychological tests, in order to verify if the parameters evaluated were maintained or presented alteration. Individuals in the supplement group received a daily dose of an oral food supplement (Souvenaid®). The study was completed with 46 patients, 22 of the control group and 24 of the supplement group. Results: During the followup period, the participants in the supplement group presented improvement in the condition of depression. It was also possible to note the improvement in attention and learning capacity, since they continued to learn throughout the evaluated period, unlike the control group, which did not keep the same pattern. The results found for the MMSE did not present statistically significant differences. The MoCA reflected the overall evaluation of our sample, which was improved in several aspects such as depression, memory and functionality, mainly for the supplement group. The nutritional status of the volunteers was evaluated from the Bory Mass Index (BMI) and the same did not present alteration of their classification between the groups and during the accompanied period. Conclusion: The use of the nutritional supplement of specific composition showed some evidence of a beneficial effect on the functional cognitive aspect of individuals with CCL over the assessed period. We did not find results that could make a correlation between nutritional status and the cognition of individuals with CCL. Other studies are needed to better evaluate aspects that may benefit this population, especially those that correlate nutritional aspects with cognition.