Alteração da atividade da superóxido dismutase e glutationa peroxidase nos estados de ultra alto risco para psicose

• Ano de defesa: 2017
• Autor(a) principal: Rios, Adiel Carneiro [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Ultra high risk; Prodromal; Oxidative stress; Antioxidant enzymes; Schizophrenia; Psychoses; Ultra alto risco; Estresse oxidativo; Enzimas antioxidantes; Esquizofrenia
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=5015874; http://repositorio.unifesp.br/handle/11600/50082

The high risk for psychosis (HRP) comprises a set of psychotic symptoms such as changes in perception and thoughts. The concept was developed to facilitate the detection and early intervention in these disorders. Strategies to identify individuals with high risk for psychosis in addition to enabling early intervention can determine the actual risk of conversion to psychosis and thus improve measures of prediction and psychosis control. New approaches have been used to understand mental disorders, such as schizophrenia. The models of clinical staging, is particularly useful in the early and milder clinical presentations of the disease. Studies suggest the presence of a deregulation of oxidative stress in psychiatric disorders such as schizophrenia and in the first episode of psychoses. However, very little is known about oxidative stress before disease onset. The aim of this study was to compare the serum levels of superoxide dismutase and glutathione peroxidase in 13 young ultra high risk (UHR) subjects with psychosis to 29 healthy control (HC) subjects matched for age and sex. The clinical profile was evaluated using the Comprehensive Assessment at Risk of Mental Status (CAARMS), Semi- Structured Clinical Interview for AXIS-I of DSM-IV (SCID-I) or Kiddie-SADS-Present and Life Version K-SADS-PL) and Global Functioning Assessment (GFA). The activities of plasma superoxide dismutase (PSD) and glutathione peroxidase (GPx) were measured in serum by the spectrophotometric method using enzyme immunoassay kits and were compared between the two groups. The results indicate a significant reduction in the enzymatic activity of PSD and GPX in the UHR group compared to the control group. There were also positive correlations between the GFA performance score and the GPx and SOD activities. The results suggest that oxidative imbalances may be present in the early stages of psychosis, even at risk stages. Future studies should replicate and expand these results.