Polimorfismos do receptor de estrogênios e sua eventual associação com os níveis do hormônio: folículo-estimulante (Fsh), hormonio luteinizante (Lh) e indice menopausal de Kupperman em mulheres na pós-menopausa

• Ano de defesa: 2015
• Autor(a) principal: Lima, Erika Knabben de [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: menopause; hormones; menopausa; hormonio
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=3213474; https://repositorio.unifesp.br/handle/11600/47269

The post menopause has gained prominence since women survive this phase a third to half of their lives, typically show symptoms of decreased estrogen production and increased production of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). These symptoms can be interpreted using the Kupperman Menopausal Index (IMK). Some authors suggest that the presence of polymorphisms (SNPs) in the estrogen receptor gene may provide a different profile to that female. The account of the activity of these receptors and their SNPs do not lead to a common census, for this reason, we conducted a molecular polymorphisms XbaI, PvuII, HaeIII and MspI in postmenopausal women, in order to observe the behavior of the levels of FSH and LH and polymorphic variation in these individuals. We use 3 mL of peripheral blood from 100 postmenopausal women with early results and annual blood tests (FSH, LH) and questionnaire IMK. The extraction was done with GFX Kit ® from Amersham-Pharmacia Biotech and conducted four separate PCR-RFLP for identification of each polymorphism. In our study the PvuII T SNP seems to be related to the increase of serum FSH polymorphism and Hae classes with higher values in the index Kuppermam women in the postmenopausal period. The remaining associations between the SNPs studied and the explanatory variables showed no significant result.