Avaliação do climatério nas mulheres com deficiência isolada do hormônio de crescimento em Itabaianinha-SE

• Ano de defesa: 2006
• Autor(a) principal: Menezes, Menilson
• Orientador(a): Oliveira, Manuel Hermínio de Aguiar
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Sergipe
• Programa de Pós-Graduação: Pós-Graduação em Ciências da Saúde
• País: BR
• Palavras-chave em Português: Climatério; Deficiência do hormônio do crescimento; IGF-I; Menopausa; Endocrinologia; Ginecologia
• Palavras-chave em Inglês: Climateric; Growth hormone deficiency; IGFI; Menopause; Endocrinology; Gynaecology
• Área do conhecimento CNPq: CNPQ::CIENCIAS DA SAUDE::MEDICINA
• Link de acesso: https://ri.ufs.br/handle/riufs/3833

The impact of isolated growth hormone deficiency (IGHD) in physiology and clinical presentation of climateric it s not known. Climateric state in normal persons, presents hormonal profile alteration, principally increase in FSH and estradiol decrease, characterizing a hypergonadotrophic and hypoestrogenic state, due to the ovarian follicular decrease. IGHD limits linear growth, but overcoat to accented diminution of insuline like growth factor (IGF1) and consequently promote alteration in muscle, bone, fat, glucosis metabolism and corporal mass index. Our objectives are evaluating intensity of climateric symptoms, hormonal alterations, and metabolic alterations and identify morbidity on this period. It was realized transversal cut study in two groups. Goup 1 with 7 persons with isolated growth hormone deficiency in Itabaianinha-SE city , homozygots to growth hormone receptor s mutation. Group 2, with 13 persons with normal growth hormone. All persons with age between 40 and 65 years old and FSH above 20mUI/ml. It was utilized clinical card, Kupperman s menopause index, blood dosage of FSH, LH, prolactin, estradiol, total cholesterol, LDL, HDL, triglycerides and glycemia. Oncotic colpocytology and image exams like pelvic ultra-sound, mammography and mammary ultra-sound. Statistical analyses were provided by hypotheses comparation utilizing SPSS software, version 12. To comparate variables media, T-Student, Mann-Witney and frequency test x2 was utilized, with p<0.05. Results presented antropometric data, like weight and high, IGHD (36.41kg ± 7.29 and 117cm ± 4.08) and control (62.26kg ± 11.42 and 154.12cm ± 6.38) with p<0.05. Kupperman s menopause index in IGHD and control groups had small intensity (13.20 ± 9.30 and 16.00 ± 10.50). In climateric symptoms proportion of insomnia in IGHD and control groups (57% and 46%) with p=0.053. Reproductive aspects in IGHD and control groups presented, in menarche age (17 and 13 years old, with p<0.05), first sexual relationship age (28 and 19 years old, with p=0.065), gestation number (2 and 5, with p<0.05). Hormonal profile characteristic for climateric, just prolactin in IGHD and control groups (3.90ng ± 1.90 and 6.60ng ± 3.26) p<0.05. On metabolic profile, glycemia in IGHD and control groups (105.90mg/dl ± 13.40 and 91.43mg/dl ± 13.18) with p<0.05, showing IGHD group biologically being the group probally disglycemic. Uterus volume in IGHD and control groups (42.30cm3 ± 9.78 and 88.68cm3 ± 63.13) were normal, but IGHD group presented this volume in minumum limit of normality. In IGHD and control groups, endometrial volume (0.64cm ± 0.14 and 0.67cm ± 0.30) and ovary volume (3.13cm3 ± 1.52 and 4.00cm3 ± 2.85) had not significance. Mammography in IGHD group 85,2% BI-RADS 1 normal breast and 61.5% in control group. Oncotic colpocytology in IGHD group presented inflammatory process 42.9% and in control group 61.5%. Conclusion: Climateric in IGHD patients had not presented differences in clinical aspects and hormonal profile. However, morbidity in IGHD group was benign with breast cysts, vaginal inflammation, tendency to a small hypertension and disglycemia.