Abordagens diagnósticas na Síndrome da Apneia Obstrutiva do Sono

• Ano de defesa: 2009
• Autor(a) principal: Bittencourt, Lia Rita Azeredo [UNIFESP]
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Sleep apnea; Diagnostic; Polysomnography; Portable devices; Upper airway; Apneia do sono; Diagnóstico; Polissonografia; Via aérea superior; Monitorização portátil
• Link de acesso: https://repositorio.unifesp.br/handle/11600/58761

The Obstructive Sleep Apnea Syndrome (OSAS) is high prevalent and has as consequences excessive daytime sleepiness, risk of labor and traffic accidents, cognitive impairment, mood alterations, metabolic and cardiovascular diseases that compromise the health, the quality of life and surveillance of the patients. Still, the syndrome is not always adequately diagnosed, due especially to physicians’ limited acquaintance, patients’ misperception of signs and symptoms and to the complexity of diagnostic methods. In this dissertation it will be presented and discussed the main publications of my line of research concerning limitations on OSAS diagnostic approaches. The polysomnography (PSG) is considered the gold standard method for evaluating the syndrome; nevertheless, the reproductibility of measured parameters during the exam had not been completed evaluated. On my doctorate thesis, I attested that there is an individual variability of the apnea and hypopnea index (AHI), the metric measure used in the PSG for OSAS’s diagnose and treatment follow-up. Thereafter we sought to develop a systematic evaluation model of the upper airway that could simply and practically contribute to a diagnostic approach. Such model demonstrated a significant relationship with the presence and severity of OSAS in a sample of patients presenting the syndrome. Later on, in other two studies, one comparing patients and controls, and other comparing obese with and without OSAS, the model was able to differentiate groups and to demonstrate relationship to OSAS independently of obesity. In addition to this line of research, we demonstrated the accuracy of portable devices for cardio-respiratory ambulatory register, in diagnosing patients with high clinical probability for OSAS. With these results we prove the validity of simplified clinical and register methods for OSAS.