Manipulação ambiental e farmacológica induz respostas comportamentais e endócrinas similares em peixe-zebra

• Ano de defesa: 2016
• Autor(a) principal: Giacomini, Ana Cristina Vendrametto Varrone
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Santa Maria; BR; Farmacologia; UFSM; Programa de Pós-Graduação em Farmacologia
• Palavras-chave em Português: Cortisol; Comportamento; Psicofármacos; Enriquecimento ambiental; Behavior; Psychoactive drugs; Environmental enrichment; CNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA
• Link de acesso: http://repositorio.ufsm.br/handle/1/3857

The physiological and behavioral responses can vary with the form of housing of the fish and the presence of anxiolytic drugs. The aim of this study was to evaluate the response to acute stress in isolated and grouped fish and the effect of fluoxetine, diazepam and environmental enrichment on behavioral and endocrine parameters. Six experiments were performed: 1. Acute stress test in isolated and groups zebrafish; 2. Transfer of isolated or group zebrafish to a new environment; 3. Effect of introducing grouped stressed fish in a resident zebrafish shoal; 4. Effect of introducing one stressed fish in a resident zebrafish shoal; 5. Effect of acute exposure to fluoxetine and diazepam on behavioral responses after acute stress protocol; 6. Response to acute stress in isolated and grouped fish and the modulation by fluoxetine, diazepam and environmental enrichment. Based on the results we concluded that the group is able to potentiate stress response, however, that response is reduced by exposure to fluoxetine and diazepam in water and environmental enrichment; acute exposure to fluoxetine and diazepam modulates behavior in zebrafish after acute stress.