Atividade amebicida do óleo essencial de plantas do gênero Lippia (Verbenaceae) frente a trofozoítos de Acanthamoeba polyphaga

• Ano de defesa: 2014
• Autor(a) principal: Santos, Israel Gomes de Amorim
• Orientador(a): Dolabella, Silvio Santana
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Sergipe
• Programa de Pós-Graduação: Pós-Graduação em Biologia Parasitária
• País: BR
• Palavras-chave em Português: Acanthamoeba polyphaga; Lippia spp.; Carvacrol; Carvona; rotundifolona; Atividade amebicida; Plantas medicinais; Essencias e óleos essenciais
• Palavras-chave em Inglês: Carvone; Rotundifolona; Amebacide activity
• Área do conhecimento CNPq: CNPQ::CIENCIAS BIOLOGICAS::PARASITOLOGIA
• Link de acesso: https://ri.ufs.br/handle/riufs/3261

Amebic keratitis and granulomatous amebic encephalitis are diseases caused by free-living amoebas of the Acanthamoeba type. In the case of keratitis, the great problem is the relapse of this disease because of its resistance to medicines used for it, especially the cystic form of the organism. Plant essential oils have been used as potentially active agents against this protist. Therefore, the objective of this study was to determine the amebacide activity of plant essential oils of Lippia type against Acanthamoeba polyphaga trophozoites. To do this, 8 x 104 trophozoites were exposed to increased concentrations of essential oils of Lippia sidoides, Lippia gracilis, Lippia alba and Lippia pedunculosa during 24 hours, as well as of their majority compounds rotundifolona, carvone and carvacrol. Practically all the oil and compound concentrations presented amebacide activity. Based on these results, the researched oils in this study are potential candidates for a complementary healing for amebic keratitis and granulomatous amebic encephalitis.