Uso de antimicrobianos em unidades de terapia intensiva pediátrica e adulta de um hospital público terciário

• Ano de defesa: 2013
• Autor(a) principal: Marcelino, Flávio Augusto Brito
• Orientador(a): Lyra Júnior, Divaldo Pereira de
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Sergipe
• Programa de Pós-Graduação: Pós-Graduação em Ciências da Saúde
• País: BR
• Palavras-chave em Português: Antimicrobianos; Unidade de Terapia Intensiva; Revisão de Uso de Medicamentos
• Palavras-chave em Inglês: Antimicrobial; Intensive Care Unit; Drug Utilization Review
• Área do conhecimento CNPq: CNPQ::CIENCIAS DA SAUDE
• Link de acesso: https://ri.ufs.br/handle/riufs/3867

The high use and often inappropriate antimicrobial is the main factor related to increased incidence of multiresistant microorganisms . This fact highlights the need to promote rational use through actions , such as monitoring the use of these drugs . The present study aimed to characterize the pattern and trends of antimicrobial use , comparing pediatric intensive care units ( ICU -PED ) and adult ( AD - ICU ) between July 2006 and June 2011 , in a public hospital high complexity of the state of Sergipe . This is a study of time series using data collected prospectively by the Office of Infection Control ( HICS ) hospital study on the use of antimicrobials . To measure the use of these drugs , we calculated the percentage and density and incidence rates per 1,000 patient-days , by means of measurement units : days of treatment ( DOT ) and treatment period (LOT ) . As a result it was observed that the percentage of use of these drugs was greater than 80 % in both units , with greater frequency among pediatric patients . During the study were recorded incidence density of 1,530.8 DOT/1.000 patient-days of all antimicrobials in the ICU and ICU -PED -AD DOT/1.000 1,344.4 patient-days . The most frequently used were cephalosporins , carbapenems and glycopeptides . By analyzing the temporal trend of the use of these drugs was observed that cefepime and ceftriaxone showed a downward trend , with increased use of carbapenems in the two ICUs . The drugs were more likely to increase over time were : polymyxin B ICU -AD and antifungal ICU -PED . The median antibiotic use differed between the two ICUs ( p < 0.005 ) , except for : ceftriaxone , carbapenems , ciprofloxacin , however the median LOT were equivalent . The use of antimicrobials by DOT and LOT demonstrated trend towards increasing in both units and different usage pattern , showing the relevance of this monitoring as part of the programs for the rational use of antimicrobials and control multiresistant microorganisms .