Estudos toxicológicos não-clínicos dos infuso e extratos secos nebulizados das drogas vegetais Myracrodruon urundeuva Allemão (aroeira), Poincianella pyramidalis Tul. (catingueira) e Anadenanthera colubrina var. cebil (angico)

• Ano de defesa: 2017
• Autor(a) principal: Salvador, Islaine de Souza
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal da Paraíba; Brasil; Farmacologia; Programa de Pós-Graduação em Desenvolvimento e Inovação Tecnológica em Medicamentos; UFPB
• Palavras-chave em Português: Myracrodruon urundeuva; Poincianella pyramidalis; Anadenanthera colubrina; Quercetina; Canferol; Toxicidade Dose única; Toxicidade em doses repetidas; Quercetin; Single dose Toxicity; Repeated doses toxicity; CNPQ::CIENCIAS DA SAUDE::FARMACIA
• Link de acesso: https://repositorio.ufpb.br/jspui/handle/123456789/11241

The plants Myracrodruon urundeuva (aroeira), Poincianella pyramidalis (catingueira) and Anadenanthera colubrina (angico), are commonly used in the popular medicine of Cariri Paraibano, for the treatment of various intestinal, gynecological, healing and respiratory diseases. The objective of this study was to evaluate the acute non - clinical toxicological profile of infusions and nebulized dry extracts of the plant drugs of M. urundeuva, P. pyramidalis and A. colubrina. The powder infusions of the plant drugs of the studied plants were evaluated in the sizes of particles of coarse powder (710-355 µm), semifinished powder (355-180 µm) and fine powder (150-75 µm) in the swiss Single dose, evaluated for 14 days, regarding behavioral changes, water consumption, feed and body mass. The spray dried extracts M. urundeuva, P. pyramidalis and A. colubrina were evaluated at concentrations of 500, 1000 and 2000 mg / kg per animal in a single oral dose in male / female mice for 14 days, Observing the behavioral changes, water consumption, ration and body mass. We also determined the mass of the heart, liver, kidney, lung and spleen organs, with morphological evaluation of these organs. The repeated doses studies using the ESN of the studied plant drugs at a concentration of 2000 mg / kg / day / animal in mouse and male / female rabbits, evaluated during 30 days, regarding behavioral changes, water consumption, feed and body mass, As well as mass of the heart, liver, kidney, lung and spleen organs, as well as the analysis of the hematological and biochemical, morphological and histopathological parameters of the organs studied. Control groups were used by administering distilled water in mice and rabbits. The data obtained with infusions showed no signs of systemic toxicity for all particle sizes of the studied plant drugs. Singledose toxicity studies with NSAs at three concentrations also showed no behavioral change in water and feed intake, body mass, body mass, liver, kidney, lung and spleen organs. At repeated doses at the concentration of 2000 mg / kg per animal of each ESN of the plant drugs M. urundeuva, P. pyramidalis and A. colubrina, there was no evidence of systemic and behavioral toxicological changes or death in mice and rabbits treated with their respective control groups. Acute non-clinical toxicological studies have shown that the infusions and dry extracts of the species studied can be used in topical formulations at concentrations evaluated with proven safety.