Treinamento físico e neuroimunomodulação em modelo experimental de Tripanosomíase Americana

• Ano de defesa: 2009
• Autor(a) principal: Luciano Rezende Vilela
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Minas Gerais; UFMG
• Palavras-chave em Português: Neurociências; Tripanosomíase; Teste de esforço
• Link de acesso: http://hdl.handle.net/1843/BUBD-8AFEXR

In the present study we investigated the effects of physical training ontreadmill on the acute phase of Y strain T. cruzi infection in adult rats. Thetreadmill training was carried out for three weeks. We analyzed the expression of neurotrophic factors (BDNF and NGF) and cytokines (IFNã, TNFá and IL-10) in the lumbar spinal cord, sciatic nerve, skeletal muscle and serum during the acute phase of this infection. We have demonstrated by histometric analysis that physical training delays the establishment of the inflammatory process in the soleus muscle. Our results showed the occurrence of glioinflammatory nodules and parasitism of glial cells in all the infected animals submitted or notto treadmill training. We also have shown that infection the T. cruzi infection in adult rats results in increased expression of BDNF in the spinal cord. Our results indicate the importance of further studies about the effects of physical training on the experimental infection with T. cruzi in the neuromuscular system of adult rats.