Papel do sistema endocanabinoide em modelos animais de ataque de pânico

Detalhes bibliográficos
Ano de defesa: 2017
Autor(a) principal: Luara Augusta da Costa e Silva Braga Batista
Orientador(a): Não Informado pela instituição
Banca de defesa: Não Informado pela instituição
Tipo de documento: Tese
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal de Minas Gerais
UFMG
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Link de acesso: http://hdl.handle.net/1843/BUOS-B49JSS
Resumo: The main feature of panic disorder is the occurrence of panic attacks. Pharmacological treatment is made with antidepressants and benzodiazepines. The endocannabinod system is a neurotransmitter system involved in the modulation of aversive responses. Therefore, in the present study we tested the hypothesis that this system inibits panic-like behaviors in experimental animals. In the first part, we investigated the involvement of cannabinoid receptor 1 (CB1) in the antiaversive effects induced by systemic injection of alprazolam or injection of the 5-HT1A agonist, 8-OH-DPAT, in the dorsolateral periaquedutal gray (dlPAG). In addition, we tested if increasing endocannabinoid sigaling induces panicolytic effects in the escape induced by KCN. We observed that CB1 antagonism prevented the effects of alprazolam and 8-OH-DPAT. None of the drugs tested was efficacious in the escape reaction induced by KCN, however, alprazolam presented a panicolytic effect. In the last part, we showed that doxapram induces anxiogenic efffects in the elevated T maze and cellular activation of the ventrolateral portion of the PAG. It can be concluded that the endocannabinoid system is involved in the mechanism of action of panicolytic drugs, but not in the induction of panic-like behaviors induced by KCN or doxapram. Moreover, this study suggests the utilization of the hyperventilation induced by doxapram as an animal model of panic attac