Avaliação da qualidade de medicamentos fitoterápicos manipulados em Belo Horizonte (MG) : análise orgânica e inorgânica

• Ano de defesa: 2020
• Autor(a) principal: Karina do Nascimento Fernandes
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Minas Gerais; Brasil; ENG - DEPARTAMENTO DE ENGENHARIA NUCLEAR; Programa de Pós-Graduação em Ciências e Técnicas Nucleares; UFMG
• Palavras-chave em Português: Fitoterápicos; Controle de qualidade; HR-ICP-MS; HPLC-DAD-MS; GC-MS; Engenharia nuclear
• Link de acesso: http://hdl.handle.net/1843/35187

The use of plants for medicinal purposes is a very old practice. And although the advancement of products in the pharmaceutical sector is notable, it is considered that countless people still use this source as an herbal medicine for disease prevention and treatment. There is a growing world market in the investment of herbal medicines, which makes a greater need for health surveillance and specific agencies in the supervision and establishment of specific laws regarding the quality control and manufacture of raw materials and final products. Therefore, in this study, thirty herbal medicines were used, 25 Passiflora incarnata (P1 to P25) and 1 sample each of Equisetum arvense (CL), Maytenus ilicifolia (ES), Melissa officinalis (EC), Ginkgo biloba (GB ) and Valeriana officinalis (VL) from different regions of Belo Horizonte to carry out quality control and determine the presence of metals and organic compounds harmful to human health. In the first stage, all herbal medicines were analyzed. Regarding the values of the masses of the capsules presented, only the samples of plants P5, P11, P13, P15, P16, P22 and P25 were within the established norms. When presenting labels, only samples P2, P10, P12, P15 and P22 were in compliance. For the list of sample costs, performed for the Passiflora, the drug P25 had the best price. The analysis of inorganics by HR-ICP-MS (High Resolution Inductively Coupled Plasma Mass Spectrometry) of samples of the P1, P2, P4, P8, P12, ES, EC, VL, GB and CL plants showed concentrations of the elements 51V, 55Mn, 63Cu, 75As, 78Se, 108Pd, 111Cd, 195Pt, Hg, 208Pb below concentrations established by the National Health Surveillance Agency (ANVISA) and current pharmacopoeias. In the analysis of organic compounds made by HPLC-DAD (High Performance Liquid Chromatography coupled Diode Array Detection) and HPLCMS (High Performance Liquid Chromatography coupled Mass Spectrometry) thirty-three substances were identified in samples from plants P, EC, VL, GB and CL: flavonoids, sesquiterpenes and monoterpenes. In the VL plant, by GC-MS (Gas Chromatography coupled Mass Spectrometry), eight substances belonging to the species and three substances (Alloaromadendrene, Butylhydroxytoluene e Squalene) not belonging, which were possibly used as antioxidants / preservatives. The results obtained didn’t demonstrate the presence of compounds at a toxic level for the consumer.