Avaliação dos fatores de risco para ocorrência de bacteriemia em pacientes infectados pelo vírus da imunodeficiência humana

• Ano de defesa: 2009
• Autor(a) principal: Marcelo Silva de Oliveira
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Minas Gerais; UFMG
• Palavras-chave em Português: Sepse; Bacteriemia; HIV; AIDS; Estudos de casos; Análise multivariada; Síndrome de imunodeficiência adquirida; Medicina tropical; Fatores de risco
• Link de acesso: http://hdl.handle.net/1843/ECJS-85FJFF

This retrospective study was done between January 2001 and December 2007, in a 45- bed unit in AIDS-reference public health care service. The aim of this study was to determine the risk factors for bacteremia. All cases were defined as HIV-infected patients with bacteremia, confirmed by blood culture. Each case was matched with anHIV-infected control who had no history of bacteremia an who was hospitalized at same dates (± 10 days) as the case. Analyzes were conducted to test the statistical significance of possible risk factors in relation to bacteremia. The groups were equivalent in age, neutrophils count, lymphocytes count and body mass index ( p> 0.05). The followingvariables were considered as potential risk factors by univariate analysis (p <0.05): previous hospitalization (p <0.001), use illicit drugs (p <0.001), peripheral catheterization (p=0.004), central venous catheterization (p = 0.041), clinical stage of disease (p = 0.007), count CD4 (p = 0.004), albumin level (p <0.001), hemoglobin level (p <0.001). Multivariate analysis was performed with a conditional logistic regression model. All variables with a P value < 0.05 in a univariate analysis were candidates and the final model was selected using stepwise selection procedure. CD4 cell count below 200/mm3, albumin level below 2.2 g / dL, past hospitalizations and drug users were associated with a strong rise in the risk of bacteremia.