Avaliação da acurácia da ressonância magnética cardiovascular como método diagnóstico precoce na rejeição do enxerto nos receptores de transplante cardíaco

• Ano de defesa: 2022
• Autor(a) principal: Anna Letícia Miranda
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Minas Gerais; Brasil; MEDICINA - FACULDADE DE MEDICINA; Programa de Pós-Graduação em Ciências Aplicadas à Saúde do Adulto; UFMG
• Palavras-chave em Português: Transplante de Coração; Rejeição do Enxerto; Ressonância magnética cardiovascular; Rejeição de Enxerto; Imageamento por Ressonância Magnética; Qualidade de Vida
• Link de acesso: http://hdl.handle.net/1843/49697; https://orcid.org/0000-0002-3884-4490

Introduction: Cardiac function is a progressive disease affecting millions of people. with 10% health of patients with an advanced quality health diagnosis Heart transplantation is indicated for patients with cardiac function in functional classes NY or IV of the NY Heart Association classification (New York Heart Association). one one year. After performing a heart transplant, one of the biggest challenges in patient management is the early detection of changes in the transplant. Cardiac rejection can cause severe and irreversible myocardial damage before clinical manifestations. To date, there is no monitoring of unauthorized exams for rejection of rejection. The literature considers an endomyocardial biopsy (EMB) the gold standard for the detection of rejection. Magnetic resonance imaging (MRI) is an invasive imaging modality not able to detect areas of fibrosis, edema and correction of alterations in the power to alter the screening power for heart transplantation. Thus, it starts from the idea that CMR, as it is able to assess all myocardial functionality, may offer an advantage when the gold standard assessment is lower. Objective: To evaluate the accuracy of CMR as a non-invasive diagnostic method for the early detection of acute transplant disease in heart transplant patients. Methods: Heart transplant patients who met the inclusion criteria were defined by CMR, analysis of the presence of myocardial fibrosis and quantification of myocardial edema, using the CVI-42 software (Circle Cardiovascular Imaging, Calgary, Canada). For image acquisition after GFR assessment, patients received 0.2 mmol/kg of non-ionic gadolinium-based contrast agent (gadodiamide 0.5mmol/ml) by intravenous puncture. Results: 26 heart transplant recipients were included in a Brazilian heart transplant referral hospital, from June 2019 to February 2022. Patients underwent BEM as a screening for graft rejection; the interval for performing the procedure was defined through the institution's protocol according to the Working Group of the International Society for Heart and Lung Transplantation system and according to clinical criteria assessed by the cardiologist. Patients were divided into two groups: without evidence of rejection (0R/n=13), and with rejection (>=2R n=13). Subsequently, the patients underwent CMR examination within a period of up to 120 hours, without any change in immunosuppressive therapy. Patients under 18 years of age, who had uncontrolled arrhythmias, glomerular filtration rate <30ml/min, or who had absolute contraindications for CMR were excluded. Patients with 1R rejection were also excluded from the study. Analyzes were blindly evaluated by two radiologists. The delayed enhancement (LGE) methodology was detected in (84.6%) of the patients with BEM>=2R and in (38.5%) of the patients without rejection (p=0.016). It can be stated that the fibrosis regression models defined by the quantitative analysis of the LGE was significant (p=0.022). Conclusion: It is concluded that the subjective and quantitative analyzes of the LGE can be promising in the screening of patients with suspected rejection, as stratification tools and possible reduction in the need for EMB.