Frequência do papilomavírus humano em ânus de mulheres sem imunodeficiêncais e com neoplasias intra-epitelial cervical

• Ano de defesa: 2008
• Autor(a) principal: Alice Capobiango
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Minas Gerais; UFMG
• Palavras-chave em Português: Reação em cadeia da polimerase (PCR); Papilomavírus humano (HPV); Colo uterino; Doenças do ânus/virologia; Colo do útero; Neoplasias do ânus; Infecções por papilomavírus; Cirurgia; Reação em cadeia da polimerase; Neoplasia intra-epitelial cervical
• Link de acesso: http://hdl.handle.net/1843/EAMA-7QRMWL

Human papillomavirus (HPV) infection at the anal region has considerably increased, concomitantly increasing the number of cancer cases in this region. This association had already been proven with the cervical cancer which suggests the virus oncogenic effect. This study aims were to assess the frequency of HPV anal infection in patients with cervical intra-epithelial neoplasia (CIN), to find out the relation between the found subtypes when present in both regions and investigate factors that influenced the occurrence of anal HPV in women with CIN. Fifty two women with age between 16 and 72 years and cervical intra-epithelial neoplasia (CIN) diagnosis, grades I,II and III were studied. Material from anus and uterine cervix were obtained to identify the virus deoxyribonucleic acid (DNA) and seven virus subtypes through polymerase chain reaction (PCR). Factors that could contribute to anal infection like number of children, number of sexual partners, smoking practice, anal manipulation and intercourse, and grade of gynecologic disease were investigate by questionnaire. From the fifty two women, anal HPV diagnoses happened in 25 (48%), and 23 (44%) of them had HPV in uterine cervix as well. In 16 (31%) the HPV diagnosis occurred only in uterine cervix and in 11 (21%) no HPV was detected in anus and uterine cervix. In conclusion, women with cervical intraepihelialneoplasia have more probability to be infected with anal HPV; there is nounanimous concordance among HPV sub-types in uterine cervix and anus and the number of children and sexual partners contribute to increase the anal infection incidence in women without immuno-deficiency, with cervical HPV infection.