AVALIAÇÃO DOS PARÂMETROS DE SOLUBILIDADE DE HANSEN DO PARACETAMOL E DE ÓLEOS ESSENCIAIS

Detalhes bibliográficos
Ano de defesa: 2013
Autor(a) principal: Azevedo, Gliciane Ramos lattes
Orientador(a): ROLEMBERG, Marlus Pinheiro lattes
Banca de defesa: Mouchrek Filho, Victor Elias lattes
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal do Maranhão
Programa de Pós-Graduação: PROGRAMA DE PÓS-GRADUAÇÃO EM QUÍMICA/CCET
Departamento: QUIMICA
País: BR
Palavras-chave em Português:
Palavras-chave em Inglês:
Área do conhecimento CNPq:
Link de acesso: http://tedebc.ufma.br:8080/jspui/handle/tede/975
Resumo: The Hansen´s solubility parameters are based on the theory that the total cohesive energy can be divided in three individual components: dispersion forces, polar energies and hydrogen bonds. The parameters are usually utilized to assess compatibility and solubility among materials. To determine those parameters, the Hansen methodology has been utilized, an easy and low cost technique in which the physical-chemical features of the substances are not required to be known. In theory, the method requires the use of more than 80 solvents to test the solubility of a solute. However, the present research proposes a short list composed of 31 solvents. The solubility parameters of paracetamol drug and of Aniba duckei Kostermans and Pimenta dióica Lindl species essential oils were investigated in this study. The method was initially validated by establishing the paracetamol solubility parameters, which led to similar results to the values defined by Hansen. Therefore, the procedure was carried out wit the essential oils of species Aniba duckei Kostermans and Pimenta dióica Lindl. The oil solubility tests results in diferent solvents were identical, therefore they achieved the same solubility parameters.