AÇÃO DA CLORPROMAZINA EM RINS DE CÃES SUBMETIDOS À ISQUEMIA E REPERFUSÃO

• Ano de defesa: 2009
• Autor(a) principal: MENEZES, Liliana Borges de
• Orientador(a): ARAÚJO, Eugênio Gonçalves de
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Goiás
• Programa de Pós-Graduação: Doutorado em Ciência Animal
• Departamento: Ciências Agrárias
• País: BR
• Palavras-chave em Português: caderina; catenina; necrose tubular aguda; urinálise; 1. Cão - Função renal - Avaliação 2. Imunoistiquímica 3. Insuficiência renal - Cães 4. Rins - Cirurgia - Cães
• Palavras-chave em Inglês: fenotiazinic; gamma-glutamiltransferase; acute renal failure
• Área do conhecimento CNPq: CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA::PATOLOGIA ANIMAL::PATOLOGIA CLINICA ANIMAL
• Link de acesso: http://repositorio.bc.ufg.br/tede/handle/tde/1183

Renal ischemia is present in different situations such as vascular or kidney surgery and also in renal transplantation. The aim of this study was to evaluate the renal function in dogs submitted to ischemia and reperfusion after chlorpromazine application. Twelve adult mongrel dogs were distributed into two groups with six animals: group A - ischemia and reperfusion without previous administration of chlorpromazine; group B - ischemia and reperfusion treated previously with chlorpromazine. Blood and urine samples were harvested in four different times: before ischemia, at the beginning of reperfusion, 120 minutes after of reperfusion and every week until postsurgical day 28 in order to check the possible ischemia/reperfusion late effect. Renal function was evaluated by clinical examination, serum urea and creatinine levels and urinary GGT activity. PU/CU and urinary activity of GGT were more sensitive for detecting acute tubular injury then routine urine examination, because these variables showed earlier alterations. It was not possible to verify the chlorpromazine protective action through urinalysis, creatinine and urea serum levels, excretion of GGT urinary and urine protein:creatinine ratio.