Suplementação de ácidos graxos ômega 3 e estado nutricional de pacientes com câncer gastrointestinal

• Ano de defesa: 2011
• Autor(a) principal: MARQUES, Débora Caldas
• Orientador(a): FORNÉS, Nélida Schmid
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Goiás
• Programa de Pós-Graduação: Mestrado em Nutricao e Saude
• Departamento: Ciencias da Saude
• País: BR
• Palavras-chave em Português: Ácido docosahexaenóico; ácido eicosapentaenóico; estado nutricional; neoplasia; qualidade de vida
• Palavras-chave em Inglês: Docosahexaenoic acid; Eicosapentaenoic acid; Nutritional status; câncer; quality of life
• Área do conhecimento CNPq: CNPQ::CIENCIAS DA SAUDE::NUTRICAO
• Link de acesso: http://repositorio.bc.ufg.br/tede/handle/tde/1479

Introduction: Cancer cachexia is characterized by weight loss, immunosuppression, and is associated with a worse prognosis and quality of life. Objectives: The aim of this study was to evaluate the effects of ω-3 supplementation on nutritional and functional status and quality of life of patients with gastrointestinal cancer. Methodology: The placebo group (n = 10) received 7 caps containing 1000 mg soya oil, and the supplement group (n = 11) received 7 caps of 1000 mg fish and flaxseed oil, containing 214.3 mg of EPA and 113.5 mg of DHA, daily, for 14 days. Were assessed weight, body composition, inflammatory and immunological markers, functional status and quality of life. Results: The average weight variation of P group before and after treatment was -0.44 ± 2.7 kg and for S group was 0.07 ± 1.4 kg, with no significant differences. The average BMI of the sample was 20.5 ± 3.4 kg/m2. Significant reduction of serum total protein (p=0.005) and albumin (p=0.011) for the P group, increased levels of CRP (p=0.005), and reduction of TLC (p=0.037). An increase of serum transferrin of S group (p=0.010) and reduced levels of CRP (p=0.033) and cortisolemia (p=0.006). It was found to increase KPS (p=0.020) in group S. No differences were found for functional status, symptoms and global health. Conclusions: This study found results that support the supplementation of ω-3 in oncology. However, further investigations are necessary involvement ω-3 associated to other therapeutic strategies.