Depressão e distúrbios respiratórios do sono em pacientes com doença pulmonar obstrutiva crônica

• Ano de defesa: 2015
• Autor(a) principal: Silva Júnior, José Laerte Rodrigues da
• Orientador(a): Rabahi, Marcelo Fouad
• Banca de defesa: Rabahi, Marcelo Fouad, Porto, Celmo Celeno, Rotta, Rejane Faria Ribeiro, Rêgo, Jozelia, Ramos, Hugo Valter Lisboa
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Goiás
• Programa de Pós-Graduação: Programa de Pós-graduação em Ciências da Saúde (FM)
• Departamento: Faculdade de Medicina - FM (RG)
• País: Brasil
• Palavras-chave em Português: DPOC; Apneia obstrutiva do sono; Depressão; Fatores de risco
• Palavras-chave em Inglês: COPD; Obstructive sleep apnea; Depression; Risk factors
• Área do conhecimento CNPq: CIENCIAS DA SAUDE::MEDICINA
• Link de acesso: http://repositorio.bc.ufg.br/tede/handle/tede/4673

The chronic obstructive pulmonary disease (COPD) is a clinical condition with multiple comorbities. Among the most frequent and least treated are depression and sleep respiratory disorders. Our aim was to estimate the prevalence and predictive factors of obstructive sleep apnea (OSA) and isolated nocturnal hypoxemia, besides the predictors of major depression in clinically stable COPD subjects with mild daytime hypoxemia. A cross-sectional study followed by a case-control study was performed in clinically stable COPD subjects ≥ 40 years old, with mild daytime oxygen saturation visiting an Out Patient Chest Clinic in Goiania (Brazil). Patients were submitted to clinical and psychiatric evaluation, spirometry, 6-minute walk testing, polysomnography, echocardiography, arterial blood gas analysis and chest radiograph. During the period of study 61.4% (41/64) COPD patients were diagnosed with sleep respiratory disorders (23 with OSA and 18 with isolated nocturnal hypoxemia). PaO270mmHg (OR:4.91; 95% CI: 1.59-15.2) was significantly associated with sleep respiratory disorders and CAT score >20 was associated with major depression (OR 7.88; 95% CI 1.96 - 31.7). These findings suggests that COPD patients with mild daytime hypoxemia (PaO270mmHg) are candidate of a polysomnography and that COPD patients with CAT (COPD Assessment Test) score >20 should be submitted to an additional specific evaluation for the possible presence of major depression.