Impacto do envelhecimento na resposta imune de camundongos BALB/C e C57BL/6 contra a leishmaniose visceral

• Ano de defesa: 2019
• Autor(a) principal: Salgado, Caio Loureiro
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal do Espírito Santo; BR; Mestrado em Doenças Infecciosas; Centro de Ciências da Saúde; UFES; Programa de Pós-Graduação em Doenças Infecciosas
• Palavras-chave em Português: Immunosenescence; Memory T cells; Imunosenescência; Leishmania infantum; Células T de memória; Leishmania; Linfócitos; Envelhecimento; Doenças Infecciosas e Parasitárias; 61
• Link de acesso: http://repositorio.ufes.br/handle/10/11149

Due to its high prevalence and severity, visceral leishmaniasis has acquired great importance for epidemiological surveillance. Although it is a disease that affects different age groups, older individuals are further harmed by the disease, as aging is characterized by the reduction of the immune system which is titled Immunosenescence. This a term used to define the physiological decline of immune functions resulting from aging. It is associated with induction of multiple phenotypic and dysfunctional characteristics in the T cell pool and impaired ability to mount effective immune responses against pathogens and a satisfactory vaccine response. Immunity to Leishmania infantum infection requires a specific Th1 immune response, responsible for inducing the leishmanicidal mechanisms mediated by macrophages. In the present study, we investigated whether the immune changes imprinted by aging would have an impact on the fate of visceral. We evaluated the functional capacity of effector T cells as well as the memory differentiation profile in the T cell pool during infection of both BALB/c and C57BL/6 strains.